BIOLOGICAL SURVEYING OF DIVERSE SCHIFF BASE COMPOUNDS: ANTIPROLIFERATIVE, ANTIRADICAL AND ENZYME INHIBITION ACTIVITY

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Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Schiff base compounds (((1Z,1'Z)-(((ethane-1,2-diylbis(sulfanediyl))bis(2,1-phenylene))bis(azanylylidene)) bis(methanylylidene))bis(4,1-phenylene))diboronic acid (1), 1,1'-((1Z,1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(naphthalen-2-ol) (2), 4,4'-((1Z, 1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(2-methoxy phenol) (3), (N 4 Z, N 4'Z)-N 4, N 4'-bis(4-(dimethyl amino)benzylidene)-[1,1'-biphenyl]-4,4'-diamine (4), (E)-2-((2-hydroxybenzylidene)amino)terephthalic acid (5), and (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)terephthalic acid (6) have been synthesized. The structural identification was confirmed by spectroscopic techniques. The antiproliferative, antiradical, and enzyme activities were investigated in biological experiments. The obtained results showed that Schiff base compounds 1 - 6 exhibited meaningful features in various biological tests. A comparison of compound 1 (containing boron atom in the structure) to compounds 2 - 6 shows that the inclusion of boron in the Schiff base determines whether this would increase or not the efficiency in biological experiments. Hereby, compound 1 exhibited significantly different results in all applications.

Açıklama

Anahtar Kelimeler

Schiff Base Compounds, Antiproliferative Activity, Antiradical Activity, Enzyme Inhibitory Activity

Kaynak

Pharmaceutical Chemistry Journal

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

53

Sayı

4

Künye