BIOLOGICAL SURVEYING OF DIVERSE SCHIFF BASE COMPOUNDS: ANTIPROLIFERATIVE, ANTIRADICAL AND ENZYME INHIBITION ACTIVITY
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Schiff base compounds (((1Z,1'Z)-(((ethane-1,2-diylbis(sulfanediyl))bis(2,1-phenylene))bis(azanylylidene)) bis(methanylylidene))bis(4,1-phenylene))diboronic acid (1), 1,1'-((1Z,1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(naphthalen-2-ol) (2), 4,4'-((1Z, 1'Z)-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene)) bis(methanylylidene))bis(2-methoxy phenol) (3), (N 4 Z, N 4'Z)-N 4, N 4'-bis(4-(dimethyl amino)benzylidene)-[1,1'-biphenyl]-4,4'-diamine (4), (E)-2-((2-hydroxybenzylidene)amino)terephthalic acid (5), and (E)-2-(((2-hydroxynaphthalen-1-yl)methylene)amino)terephthalic acid (6) have been synthesized. The structural identification was confirmed by spectroscopic techniques. The antiproliferative, antiradical, and enzyme activities were investigated in biological experiments. The obtained results showed that Schiff base compounds 1 - 6 exhibited meaningful features in various biological tests. A comparison of compound 1 (containing boron atom in the structure) to compounds 2 - 6 shows that the inclusion of boron in the Schiff base determines whether this would increase or not the efficiency in biological experiments. Hereby, compound 1 exhibited significantly different results in all applications.
Açıklama
Anahtar Kelimeler
Schiff Base Compounds, Antiproliferative Activity, Antiradical Activity, Enzyme Inhibitory Activity
Kaynak
Pharmaceutical Chemistry Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
53
Sayı
4
