Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

dc.contributor.authorTuran, Nedim
dc.contributor.authorBenekli, Mustafa
dc.contributor.authorUnal, Olcun Umit
dc.contributor.authorUnek, Ilkay Tugba
dc.contributor.authorTastekin, Didem
dc.contributor.authorDane, Faysal
dc.contributor.authorAlgin, Efnan
dc.date.accessioned2024-04-24T17:24:08Z
dc.date.available2024-04-24T17:24:08Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.en_US
dc.identifier.doi10.3978/j.issn.1000-9604.2015.08.03
dc.identifier.endpage416en_US
dc.identifier.issn1000-9604
dc.identifier.issn1993-0631
dc.identifier.issue4en_US
dc.identifier.pmid26361410
dc.identifier.scopus2-s2.0-84940553386
dc.identifier.scopusqualityN/A
dc.identifier.startpage408en_US
dc.identifier.urihttps://doi.org/10.3978/j.issn.1000-9604.2015.08.03
dc.identifier.urihttps://hdl.handle.net/11468/19443
dc.identifier.volume27en_US
dc.identifier.wosWOS:000360940900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherChinese Journal Cancer Research Coen_US
dc.relation.ispartofChinese Journal of Cancer Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPancreatic Adenocarcinomaen_US
dc.subjectAdjuvant Chemotherapy (Adjuvant Ct)en_US
dc.subjectAdjuvant Radiotherapyen_US
dc.titleImpact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinomaen_US
dc.titleImpact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma
dc.typeArticleen_US

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