A high oxidative stress index predicts endothelial dysfunction in young male smokers

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dc.contributor.authorKarahan, O.
dc.contributor.authorManduz, S.
dc.contributor.authorBektasoglu, G.
dc.contributor.authorZorlu, A.
dc.contributor.authorTurkdogan, K. A.
dc.contributor.authorBozok, S.
dc.date.accessioned2024-04-24T17:24:18Z
dc.date.available2024-04-24T17:24:18Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractExperimental studies have shown that smoking was related to endothelial dysfunction via oxidative stress. However, the degree of oxidative stress to be associated with endothelial dysfunction is unknown. Oxidative stress index (OSI) might be a useful and easy way of determining the endothelial dysfunction. Hence, we aimed to evaluate the relationship between OSI and flow mediated dilatation (FMD) in smoking healthy male volunteers. Eighty smoking healthy male volunteers were enrolled in the study. Participants were classified as having normal and abnormal FMD response. In an univariate analysis; systolic and diastolic blood pressures, C-reactive protein (CRP), low-density lipoprotein cholesterol, OSI and lipid peroxidation (LPO) levels were predictive for abnormal FMD response. In a multivariable logistic regression analysis with forward stepwise method, OSI (OR: 3.194, 95% CI: 1.710-5.966, p<0.001) and CRP (OR: 2.082, 95% Cl: 1.101-3.939, p 0.024) were found to be independent parameters for predicting abnormal FMD response in young male smokers. The optimal cut-off value of OSI for detecting abnormal FMD response was found to be >3.35, with 100 % sensitivity and 84.1 % specificity. We have shown that critical endothelial dysfunction can easily be detected by OSI in individuals, at risk for developing coronary artery disease, such as smokers (Tab. 3, Fig. 3, Ref. 30). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2013_152
dc.identifier.endpage725en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid24329512
dc.identifier.scopus2-s2.0-84890887063
dc.identifier.scopusqualityQ2
dc.identifier.startpage721en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2013_152
dc.identifier.urihttps://hdl.handle.net/11468/19594
dc.identifier.volume114en_US
dc.identifier.wosWOS:000330415700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh Oxidative Stress Indexen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectYoung Male Smokersen_US
dc.subjectSystolic Blood Pressureen_US
dc.subjectDiastolic Blood Pressureen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectLow-Density Lipoproteinen_US
dc.subjectCholesterolen_US
dc.subjectLipid Peroxidationen_US
dc.subjectCoronary Artery Diseaseen_US
dc.titleA high oxidative stress index predicts endothelial dysfunction in young male smokersen_US
dc.titleA high oxidative stress index predicts endothelial dysfunction in young male smokers
dc.typeArticleen_US

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