Comparison of the effectiveness of some pleural sclerosing agents used for control of effusions in malignant pleural mesothelioma

dc.contributor.authorSenyigit, A
dc.contributor.authorBayram, H
dc.contributor.authorBabayigit, C
dc.contributor.authorTopçu, F
dc.contributor.authorBalci, AE
dc.contributor.authorSatici, Ö
dc.date.accessioned2024-04-24T17:12:20Z
dc.date.available2024-04-24T17:12:20Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives: Management of malignant pleural mesothelioma (MPM) has been an important clinical issue regardless of the treatment modality employed. We aimed to investigate the efficacy of oxytetracycline (OT), Corynebacterium parvum (CP), and nitrogen mustard (NM) in the management of pleural effusion associated with MPM. Methods: One hundred and seventeen patients who had stage-2 MPM or over according to the Butchart staging system and unilateral or bilateral pleural effusion took part in the study. The patients received either OT (35 mg/kg), CP (7 mg), or NM (0.4 mg/ kg) through a chest tube for pleurodesis. The association between several clinical parameters and patient survival was also investigated. Results: OT was applied to 59, CP to 29 and NM to 29 cases. A statistical analysis of the results obtained by these agents have demonstrated that OT (30 days, 81%; 90 days, 76.2%) and CP (30 days, 86.2%; 90 days, 79.3%) led to a significantly higher rate of successful pleurodesis as compared to NM (30 days, 48.2%; 90 days, 41.3%; p <0.05). Although the procedure was generally well tolerated by the patients, the NM-treated group experienced significantly more nausea-vomiting (46.1%) and hypotension (35.8%) compared to patients who received OT (nausea-vomiting and hypotension 4.3%; p < 0.001) and CP (nausea-vomiting and hypotension 5.1%; p < 0.001). Furthermore, we found that thrombocytosis, chest pain and weight loss were significantly associated with poor prognosis, whereas epithelial type had a positive effect on survival. Conclusion: These results suggest that OT and CP may be used as effective sclerosing agents for pleurodesis in the control of pleural effusions associated with MPM, without major side effects. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000056291
dc.identifier.endpage629en_US
dc.identifier.issn0025-7931
dc.identifier.issn1423-0356
dc.identifier.issue6en_US
dc.identifier.pmid11124644
dc.identifier.scopus2-s2.0-0034534914
dc.identifier.scopusqualityQ1
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1159/000056291
dc.identifier.urihttps://hdl.handle.net/11468/17935
dc.identifier.volume67en_US
dc.identifier.wosWOS:000166061500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespiration
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectPleurodesisen_US
dc.subjectOxytetracyclineen_US
dc.subjectCorynebacterium Parvumen_US
dc.subjectNitrogen Mustarden_US
dc.titleComparison of the effectiveness of some pleural sclerosing agents used for control of effusions in malignant pleural mesotheliomaen_US
dc.titleComparison of the effectiveness of some pleural sclerosing agents used for control of effusions in malignant pleural mesothelioma
dc.typeArticleen_US

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