Modulatory Effects of Lycopene and Ellagic Acid on Reproductive Dysfunction Induced by Polychlorinated Biphenyl (Aroclor 1254) in Male Rats

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dc.contributor.authorAtessahin, Ahmet
dc.contributor.authorTurk, Gaffari
dc.contributor.authorYilmaz, Seval
dc.contributor.authorSonmez, Mustafa
dc.contributor.authorSakin, Fatih
dc.contributor.authorCeribasi, Ali Osman
dc.date.accessioned2024-04-24T17:11:39Z
dc.date.available2024-04-24T17:11:39Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate the possible protective effects of lycopene (LP) and ellagic acid (EA) on aroclor (AR) 1254-induced testicular and spermatozoal toxicity associated with the oxidative stress and apoptosis in male rats. The control group was treated with placebo. LP (10 mg/kg/every other day), EA (2 mg/kg/every other day) and AR (2 mg/kg/day) groups were given alone LP, EA and AR respectively. One of the last two groups received AR + LP, and the other treated with AR + EA. Body and reproductive organ weights, epididymal sperm characteristics, testicular tissue lipid peroxidation levels, antioxidant enzyme activities, histopathological changes and apoptosis via Bax and Bcl-2 genes were investigated. AR administration caused statistically significant decreases in body-weight, epididymal sperm concentration, testicular superoxide dismutase activity, diameters of seminiferous tubules, germinal cell layer thickness and Johnsen's testicular score, and increases in relative weights of testis, epidydimis and seminal vesicles, rates of abnormal sperm and apoptotic cell expression along with degeneration, desquamation and disorganization in spermatogenic cells, and interstitial oedema and congestion in testicular tissue. LP and EA treatments to AR-treated rats markedly decreased abnormal sperm rates, testicular thiobarbituric acid reactive substances level, and increased the glutathione (GSH) level, GSH-peroxidase, catalase activities and epidiymal sperm concentration as compared with the alone AR group. Additionally, the AR-induced histopathological damages were totally or partially recovered by LP or EA administrations respectively. AR damages the testicular tissue and spermatozoa by impairing the oxidant/antioxidant balance and by increasing the apoptotic spermatogenic cell rates. However, both LP and EA have modulator effects on AR-induced reproductive dysfunction in male rats.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [106O123]en_US
dc.description.sponsorshipThe authors acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK); Project number: 106O123.en_US
dc.identifier.doi10.1111/j.1742-7843.2009.00529.x
dc.identifier.endpage489en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue6en_US
dc.identifier.pmid20074268en_US
dc.identifier.scopus2-s2.0-77952257281en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2009.00529.x
dc.identifier.urihttps://hdl.handle.net/11468/17654
dc.identifier.volume106en_US
dc.identifier.wosWOS:000277608500007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleModulatory Effects of Lycopene and Ellagic Acid on Reproductive Dysfunction Induced by Polychlorinated Biphenyl (Aroclor 1254) in Male Ratsen_US
dc.typeArticleen_US

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