Relationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome

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dc.contributor.authorAbakay, Ozlem
dc.contributor.authorAbakay, Abdurrahman
dc.contributor.authorPalanci, Yilmaz
dc.contributor.authorYuksel, Hatice
dc.contributor.authorSen, Hadice Selimoglu
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorTanrikulu, Abdullah Cetin
dc.date.accessioned2024-04-24T16:02:27Z
dc.date.available2024-04-24T16:02:27Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was aimed to assess potential correlations between periodic leg movement (PLM) index, hepcidin levels, and iron status in patients with obstructive sleep apnea syndrome (OSAS). Forty-four newly diagnosed OSAS patients and 49 non-apneic controls were enrolled in this study. All patients underwent polysomnographic evaluation. The hepcidin, iron, ferritin, total iron binding capacity, and C-reactive protein levels were measured. The mean age was 47.4 +/- 7.2 years (18-68) in the OSAS group and 44.9 +/- 11.1 years (23-65) in the control group. There were no differences in age, gender, and smoking between OSAS patients and controls. Mean apnea-hypopnea index (AHI) was 25.1 events/h. Mean serum hepcidin levels were significantly higher in OSAS subjects (725.9 ng/ml) than in control subjects (646.0 ng/ml) (p < 0.001). Serum iron levels were significantly lower in the OSAS and PLM disorder groups than in control subjects (p < 0.001). Serum hepcidin levels were significantly correlated with AHI (r = 0.453) and PLM index (r = 0.114). Serum iron levels were significantly negatively correlated with AHI (r = -0.169) and PLM index (r = -0.180). In our study, the level of hepcidin was increased in patients with OSAS. Our study indicates that levels of hepcidin correlate with the AHI and PLM index severity of OSAS.en_US
dc.identifier.doi10.1007/s11325-014-1028-3
dc.identifier.endpage466en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue2en_US
dc.identifier.pmid25008988
dc.identifier.scopus2-s2.0-84939878185
dc.identifier.scopusqualityQ1
dc.identifier.startpage459en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-014-1028-3
dc.identifier.urihttps://hdl.handle.net/11468/14795
dc.identifier.volume19en_US
dc.identifier.wosWOS:000352909700005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive Sleep Apnea Syndromeen_US
dc.subjectHepcidinen_US
dc.subjectIronen_US
dc.subjectPeriodic Limb Movement Indexen_US
dc.subjectApnea-Hypopnea Indexen_US
dc.titleRelationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndromeen_US
dc.titleRelationship between hepcidin levels and periodic limb movement disorder in patients with obstructive sleep apnea syndrome
dc.typeArticleen_US

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