Effect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Rats

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dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorTurkcu, Gul
dc.contributor.authorOzler, Ali
dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorEvliyaoglu, Osman
dc.date.accessioned2024-04-24T17:14:28Z
dc.date.available2024-04-24T17:14:28Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: To determine the impact of caffeic acid phenethyl ester (CAPE) on abdominal adhesion formation after laparotomy. Methods: Forty female rats were allocated into four distinct groups on which laparotomy alone; laparotonny with traumatization of the uterine horns; laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with saline, and laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with CAPE were performed. After sacrifying the animals on the 14th postoperative day, histopathological examination and biochemical analysis were conducted to evaluate the formation of abdominal adhesions and antioxidant status. Results: In the CAPE group, total adhesion scores were significantly lower than in the control and saline groups. The CAPE group displayed less inflammation, giant cell formation, fibrosis and fibroblastic activity than the control group. On the other hand, the control group displayed higher total adhesion scores. Conclusion:The results of this study indicate that the administration of CAPE may have beneficial effects for the prevention of abdominal adhesion formation after laparotomy. Further clinical studies are mandatory to explore the actual therapeutic potential of CAPE. Copyright (C) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000349893
dc.identifier.endpage288en_US
dc.identifier.issn0378-7346
dc.identifier.issue4en_US
dc.identifier.pmid23548785
dc.identifier.scopus2-s2.0-84878862077
dc.identifier.scopusqualityQ2
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.1159/000349893
dc.identifier.urihttps://hdl.handle.net/11468/17974
dc.identifier.volume75en_US
dc.identifier.wosWOS:000319854700011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectLaparotomyen_US
dc.subjectAdhesion Formationen_US
dc.titleEffect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Ratsen_US
dc.titleEffect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Rats
dc.typeArticleen_US

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