Cream production and biological in vivo/in vitro activity assessment of a novel boron-based compound derived from quercetin and phenyl boronic acid

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dc.authorid0000-0001-9225-7425en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0002-7511-7508en_US
dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorTemel, Hamdi
dc.contributor.authorAtlan, Metin
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorYener, İsmail
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYazan, Zehra
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.date.accessioned2024-03-18T13:07:32Z
dc.date.available2024-03-18T13:07:32Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBoronic acids constitute an important class of synthetic intermediates due to their high chemical stability, ease of use, moderate organic Lewis acid properties, reduced reactivity profiles and numerous biological activities such as antibacterial and antioxidant. The present study documents the synthesis and characterization of a novel boronic ester compound (3,5,7-trihydroxy-2- (2-phenyl benzo [d] [1,3,2] dioxaborol-5-yl) −4H-chromen-4-a) which was derived from phenyl boronic acid and quercetin. The new boron-based compound was used in the cream formulation after evaluating its antioxidant, antibacterial, anti-enzyme, anticancer activities and electrochemical oxidation behaviour. Furthermore, the cream has been dermatologically and microbiologically tested. Also, histological evaluation of the agent was estimated on multiple rat organs by hematoxylin-eosin staining method. Antioxidant potential of the new compound was tested by ABTS cation radical (IC50: 0.11 ± 0.01 µg/mL), DPPH free radical scavenging (IC50: 0.14 ± 0.01 µg/mL), and CUPRAC (A0.5: 1.73 ± 0.16 µg/mL) methods, respectively. The compound determined to have a dominant antioxidant activity. In addition, the synthesized compound had no toxic effect on the healthy cell line (PDF), while having a very high (IC50: 18.76 ± 0.62 µg/mL) cytotoxic effect on the cancerous cell line (MCF-7). In general, the compound showed moderate acetylcholinesterase enzyme activity (IC50: 115.63 ± 1.16 µg/mL), high butyrylcholinesterase (IC50: 3.12 ± 0.04 µg/mL), antiurease (IC50: 1.10 ± 0.06 µg/mL), and antithyrosinase (IC50: 11.52 ± 0.46 µg/mL) enzyme activities. In addition, the compound was found to be effective against Escherichia coli (ATCC 25922) bacteria studied at concentrations of 6.50 mg/mL. Moreover, the test results of the boronic ester compound used in the cream formulation demonstrated that it was microbiologically and dermatologically appropriate. Histologic analysis showed that the control group and experimental group were at similar properties without significant change. The phenyl boronic acid derivative compound synthesized from quercetin may have higher biological activity potential than quercetin. Due to the high biological activity potential of the synthesized compound, it has the potential to be used in food, feed, pharmaceutical and cosmetic industries.en_US
dc.identifier.citationTemel, H., Atlan, M., Ertaş, A., Yener, İ., Akdeniz, M., Yazan, Z. ve diğerleri. (2022). Cream production and biological in vivo/in vitro activity assessment of a novel boron-based compound derived from quercetin and phenyl boronic acid. Journal of Trace Elements in Medicine and Biology, 74, 1-8.en_US
dc.identifier.doi10.1016/j.jtemb.2022.127073
dc.identifier.endpage8en_US
dc.identifier.issn0946-672X
dc.identifier.pmid36126542
dc.identifier.scopus2-s2.0-85138095198
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0946672X22001535?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13623
dc.identifier.volume74en_US
dc.identifier.wosWOS:000865408600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTemel, Hamdi
dc.institutionauthorAtlan, Metin
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorYener, İsmail
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAnticancer studiesen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibition activitiesen_US
dc.subjectPhenyl boronic aciden_US
dc.subjectQuercetinen_US
dc.titleCream production and biological in vivo/in vitro activity assessment of a novel boron-based compound derived from quercetin and phenyl boronic aciden_US
dc.titleCream production and biological in vivo/in vitro activity assessment of a novel boron-based compound derived from quercetin and phenyl boronic acid
dc.typeArticleen_US

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