The relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients

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dc.contributor.authorArslan, Ayse
dc.contributor.authorTuzun, Fatma Aykan
dc.contributor.authorArslan, Harun
dc.contributor.authorDemir, Halit
dc.contributor.authorTamer, Sibel
dc.contributor.authorDemir, Canan
dc.contributor.authorTasin, Muhterem
dc.date.accessioned2024-04-24T16:18:16Z
dc.date.available2024-04-24T16:18:16Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractLow paraoxonase 1 (PON1) activity and carotid atherosclerosis have been suggested to be important risk factors for dementia. However, the studies to date could not fully clarify the relationship between PON1, carotid atherosclerosis and dementia. The present study aimed to measure carotid atherosclerosis and PON1 activity in Alzheimer's Disease and to evaluate the relationship between them. The study included 25 Alzheimer's patients and 25 control subjects, for a total of 50 individuals. The study measured the serum PON1 activity and other biochemical parameters and carotid atherosclerotic plaque values of the participants. The mean paraoxonase activity (31.06 +/- 2.31 U/L) was significantly lower in the Alzheimer's group compared to the control group (59.05 +/- 7.05 U/L) (P < 0.001). Nonetheless, the carotid plaque values were significantly higher in the patient group (3.02 +/- 0.52 mm) compared to the control group (1.84 +/- 0.45 mm) (P < 0.001). Furthermore, there was a negative correlation (81.0%) between PON1 activity and carotid plaque in the overall study group (P < 0.05). Also serum homocystein level was higher in the patient group (22.15 +/- 7.05) compared to the control group (13.30 +/- 3.32). In conclusion, our findings show inverse association between PON1 activity and carotid atherosclerosis in Alzheimer patients: the lower the PON1 activity the more progressed the atherosclerotic process in AD. (C) 2016 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.en_US
dc.identifier.doi10.1016/j.pjnns.2016.07.002
dc.identifier.endpage409en_US
dc.identifier.issn0028-3843
dc.identifier.issue6en_US
dc.identifier.pmid27546893
dc.identifier.scopus2-s2.0-84982085185
dc.identifier.scopusqualityQ1
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.1016/j.pjnns.2016.07.002
dc.identifier.urihttps://hdl.handle.net/11468/15945
dc.identifier.volume50en_US
dc.identifier.wosWOS:000387934900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofNeurologia I Neurochirurgia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectPon1en_US
dc.subjectHomocysteinen_US
dc.subjectCarotid Atherosclerosisen_US
dc.titleThe relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patientsen_US
dc.titleThe relationship between serum paraoxonase levels and carotid atherosclerotic plaque formation in Alzheimer's patients
dc.typeArticleen_US

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