Diagnosis of chronic brucellar meningitis and meningoencephalitis: the results of the Istanbul-2 study

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dc.contributor.authorErdem, H.
dc.contributor.authorKilic, S.
dc.contributor.authorSener, B.
dc.contributor.authorAcikel, C.
dc.contributor.authorAlp, E.
dc.contributor.authorKarahocagil, M.
dc.contributor.authorYetkin, F.
dc.date.accessioned2024-04-24T17:11:23Z
dc.date.available2024-04-24T17:11:23Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractNo detailed data exist in the literature on the accurate diagnosis of chronic brucellar meningitis or meningoencephalitis. A multicentre retrospective chart review was performed at 19 health centres to determine sensitivities of the diagnostic tests. This study included 177 patients. The mean values of CSF biochemical test results were as follows: CSF protein, 330.64 +/- 493.28mg/dL; CSF/ blood-glucose ratio, 0.35 +/- 0.16; CSF sodium, 140.61 +/- 8.14mMt; CSF leucocyte count, 215.99 +/- 306.87. The sensitivities of the tests were as follows: serum standard tube agglutination (STA), 94%; cerebrospinal fluid (CSF) STA, 78%; serum Rose Bengal test (RBT), 96%; CSF RBT, 71%; automated blood culture, 37%; automated CSF culture, 25%; conventional CSF culture, 9%. The clinician should use every possible means to diagnose chronic neurobrucellosis. The high seropositivitiy in brucellar blood tests must facilitate the use of blood serology. Although STA should be preferred over RBT in CSF in probable neurobrucellosis other than the acute form of the disease, RBT is not as weak as expected. Moreover, automated culture systems should be applied when CSF culture is needed.en_US
dc.identifier.doi10.1111/1469-0691.12092
dc.identifier.endpageE86en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue2en_US
dc.identifier.pmid23210984
dc.identifier.scopus2-s2.0-84873526291
dc.identifier.scopusqualityQ1
dc.identifier.startpageE80en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12092
dc.identifier.urihttps://hdl.handle.net/11468/17466
dc.identifier.volume19en_US
dc.identifier.wosWOS:000314656100004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology and Infection
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronicen_US
dc.subjectDiagnosisen_US
dc.subjectMeningitisen_US
dc.subjectMeningoencephalitisen_US
dc.subjectNeurobrucellosisen_US
dc.titleDiagnosis of chronic brucellar meningitis and meningoencephalitis: the results of the Istanbul-2 studyen_US
dc.titleDiagnosis of chronic brucellar meningitis and meningoencephalitis: the results of the Istanbul-2 study
dc.typeArticleen_US

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