Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps

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dc.authorid0000-0002-8322-7475en_US
dc.authorid0000-0001-7058-3457en_US
dc.contributor.authorŞimşek, Sadullah
dc.contributor.authorİşlek, Akif
dc.date.accessioned2024-02-26T13:26:00Z
dc.date.available2024-02-26T13:26:00Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.description.abstractObjectives: Osteitis and tissue remodeling are infammatory processes associated with the severity of chronic rhinosinusitis with nasal polyps (CRSwNP). Nasal steroids are the mainly recommended therapeutics in the treatment of the disease, and besides their benefcial efects, they may worsen osteitis via osteopenia. This study aimed to search for the coalescence of osteitis in CRSwNP and nasal steroid use (NSU). Methods: A cross-sectional study was designed. Patients who underwent paranasal sinus computed tomography (PNSCT) imaging were queried, and the sino‐nasal outcome test-22 (SNOT-22) was completed. Regular NSU was defned as a continued treatment for 2 months in the last 6 months. The cumulative period of NSU during the last 6 months was determined and classifed as no use or, for 1 to 3 months, or more than 3 months. Lund-MacKay scores (LMS) and Global Osteitis Scores (GOS) were calculated for 10 sinuses via PNSCT. Results: Sixty-two patients were included in the study. The mean GOS score was 5.7±1.7 points higher in patients with regular NSU (p=0.002, 95% CI: 9.2–2.2, t-test). LMS and SNOT-22 scores also were signifcantly higher for patients with regular NSU (p=0.036 and<0.001 consecutively). The mean GOS score showed a signifcant increase according to the cumulative period of NSU (p<0.001, one-way ANOVA test). Similarly, LMS and SNOT-22 scores were also signifcantly associated with the duration of total NSU. GOS score showed a signifcant positive high correlation with LMS and SNOT-22 scores (p<0.001, r=0.608 and r=0.753 consecutively). Conclusions: This association found between the severity of GOS and NSU is probably due to the severity of the disease. However, it may question the value of the NSU efect in the development of osteitis. The presence of NSU should be investigated in future histopathological studies. Level of evidence: IVen_US
dc.identifier.citationŞimşek, S. ve İşlek, A. (2022). Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps. Egyptian Journal of Otolaryngology, 38(1), 1-6.en_US
dc.identifier.doi10.1186/s43163-022-00328-5en_US
dc.identifier.endpage6en_US
dc.identifier.issn1012-5574
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85140626291en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://ejo.springeropen.com/articles/10.1186/s43163-022-00328-5
dc.identifier.urihttps://hdl.handle.net/11468/13392
dc.identifier.volume38en_US
dc.identifier.wosWOS:000871193200005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞimşek, Sadullah
dc.language.isoenen_US
dc.publisherSpringer Medizinen_US
dc.relation.ispartofEgyptian Journal of Otolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone remodelingen_US
dc.subjectChronic rhinosinusitisen_US
dc.subjectGlobal osteitis scoreen_US
dc.subjectNasal polypsen_US
dc.subjectNasal steroiden_US
dc.subjectOsteitisen_US
dc.titleNasal steroid use and osteitis development in chronic rhinosinusitis with nasal polypsen_US
dc.typeArticleen_US

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