Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Medizin
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: Osteitis and tissue remodeling are infammatory processes associated with the severity of chronic rhinosinusitis with nasal polyps (CRSwNP). Nasal steroids are the mainly recommended therapeutics in the treatment of
the disease, and besides their benefcial efects, they may worsen osteitis via osteopenia. This study aimed to search
for the coalescence of osteitis in CRSwNP and nasal steroid use (NSU).
Methods: A cross-sectional study was designed. Patients who underwent paranasal sinus computed tomography
(PNSCT) imaging were queried, and the sino‐nasal outcome test-22 (SNOT-22) was completed. Regular NSU was
defned as a continued treatment for 2 months in the last 6 months. The cumulative period of NSU during the last
6 months was determined and classifed as no use or, for 1 to 3 months, or more than 3 months. Lund-MacKay scores
(LMS) and Global Osteitis Scores (GOS) were calculated for 10 sinuses via PNSCT.
Results: Sixty-two patients were included in the study. The mean GOS score was 5.7±1.7 points higher in patients
with regular NSU (p=0.002, 95% CI: 9.2–2.2, t-test). LMS and SNOT-22 scores also were signifcantly higher for patients
with regular NSU (p=0.036 and<0.001 consecutively). The mean GOS score showed a signifcant increase according
to the cumulative period of NSU (p<0.001, one-way ANOVA test). Similarly, LMS and SNOT-22 scores were also signifcantly associated with the duration of total NSU. GOS score showed a signifcant positive high correlation with LMS
and SNOT-22 scores (p<0.001, r=0.608 and r=0.753 consecutively).
Conclusions: This association found between the severity of GOS and NSU is probably due to the severity of the
disease. However, it may question the value of the NSU efect in the development of osteitis. The presence of NSU
should be investigated in future histopathological studies.
Level of evidence: IV
Açıklama
Anahtar Kelimeler
Bone remodeling, Chronic rhinosinusitis, Global osteitis score, Nasal polyps, Nasal steroid, Osteitis
Kaynak
Egyptian Journal of Otolaryngology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
38
Sayı
1
Künye
Şimşek, S. ve İşlek, A. (2022). Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps. Egyptian Journal of Otolaryngology, 38(1), 1-6.
