The nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-κB signal modulation activity

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dc.authorid0000-0002-1693-6378en_US
dc.authorid0000-0002-9681-4468en_US
dc.authorid0000-0002-0093-6066en_US
dc.authorid0000-0001-7939-5153en_US
dc.authorid0000-0001-6160-5626en_US
dc.contributor.authorŞeker, Uğur
dc.contributor.authorKavak, Deniz Evrim
dc.contributor.authorDokumacı, Fatma Zehra
dc.contributor.authorKızıldağ, Sefa
dc.contributor.authorKandemir, Sevgi İrtegün
dc.date.accessioned2024-06-25T12:38:40Z
dc.date.available2024-06-25T12:38:40Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractThe present study aimed to examine the protective effect of quercetin (QUE) on cyclophosphamide (CTX)-induced nephrotoxicity. For that purpose, 24 mice were divided into four groups (Control, QUE, CTX, and CTX + QUE). The CTX and CTX + QUE groups received 200 mg/kg of cyclophosphamide on the 1st and 7th days. The QUE and CTX + QUE groups were treated with 50 mg/kg of quercetin daily for 14 days. At the end of the experiment, the animals were sacrificed, and kidney samples were analyzed. The results indicated that CTX leads to severe morphological degenerations and disruption in renal function. Serum BUN, Creatinine, Uric acid, tissue Bax, Caspase 3, TNF-α and IL-1β expression levels were upregulated in the CTX group compared to Control and QUE groups (p < 0.05). Although MAPK/ERK phosphorylation level is not affected in CTX group, there was a significant increase in CTX + QUE group (p < 0.05), but the NF-κB was significantly suppressed in this group (p < 0.01). The RT-qPCR results showed that the cyt-c and the Bax/Bcl-2 ratio mRNA expression folds were upregulated in the CTX group (p < 0.01), which was downregulated in the CTX + QUE group. However, there was a significant difference in the CTX + QUE group compared to the Control and QUE groups (p < 0.01). The findings showed that administering quercetin along with cyclophosphamide alleviated renal injury by regulating apoptotic and inflammatory expression. Moreover, the administration of quercetin and cyclophosphamide could synergistically improve renal function test results, and activate cellular responses, which upmodulate MAPK/ERK phosphorylation and suppression of NF-κB.en_US
dc.identifier.citationŞeker, U., Kavak, D. E., Dokumacı, F. Z., Kızıldağ, S. ve Kandemir, S. İ. (2024). The nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-κB signal modulation activity. Drug and Chemical Toxicology, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn0148-0545
dc.identifier.pmid38726926
dc.identifier.scopus2-s2.0-85192709872
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01480545.2024.2347541
dc.identifier.urihttps://hdl.handle.net/11468/28686
dc.identifier.wosWOS:001218342200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKavak, Deniz Evrim
dc.institutionauthorDokumacı, Fatma Zehra
dc.institutionauthorKandemir, Sevgi İrtegün
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.isversionof10.1080/01480545.2024.2347541en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCyclophosphamideen_US
dc.subjectMAPK/ERKen_US
dc.subjectNephrotoxicityen_US
dc.subjectNF-κBen_US
dc.subjectQuercetinen_US
dc.titleThe nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-κB signal modulation activityen_US
dc.titleThe nephroprotective effect of Quercetin in Cyclophosphamide-induced renal toxicity might be associated with MAPK/ERK and NF-?B signal modulation activity
dc.typeArticleen_US

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