Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia

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dc.contributor.authorDemirtas, Sinan
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYazici, Suleyman
dc.contributor.authorGuclu, Orkut
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorTezcan, Orhan
dc.contributor.authorYavuz, Celal
dc.date.accessioned2024-04-24T17:28:05Z
dc.date.available2024-04-24T17:28:05Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Mesenteric arteries release C-type natriuretic peptide (CNP), which hyperpolarises vascular smooth muscle. We measured the levels of this peptide after inducing mesenteric ischaemia over a series of time intervals, so as to determine its predictive value in demonstrating the severity of ischaemia in a rat model. Methods: A total of 32 rats were allocated to four groups containing eight rats each. Basal CNP reference levels were measured in the control group, which was not exposed to any intervention. In groups I, II and III, mesenteric ischaemia was induced over three, six and nine hours, respectively, and plasma CNP levels were measured afterwards. Mesenteric ischaemia was induced by clamping the superior mesenteric artery. Results: In comparison with the controls (2.38 +/- 0.18 pg/ml), CNP levels were relatively lower in group I (2.54 +/- 0.42 pg/ml). However, significant increases in plasma CNP levels were observed over longer periods of ischaemia in group II, at 5.23 +/- 0.22 pg/ml, and in group III, at 6.19 +/- 0.67 pg/ml (p < 0.05). A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia (R = 0.56, p < 0.001). Conclusion: Measuring plasma CNP levels in patients with acute mesenteric ischaemia may be beneficial in estimating the time period over which the ischaemic injury has occurred.en_US
dc.identifier.doi10.5830/CVJA-2014-033
dc.identifier.endpage203en_US
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue5en_US
dc.identifier.pmid24967686
dc.identifier.scopus2-s2.0-84910002859
dc.identifier.scopusqualityQ3
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2014-033
dc.identifier.urihttps://hdl.handle.net/11468/20320
dc.identifier.volume25en_US
dc.identifier.wosWOS:000347478200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherClinics Cardive Publ Pty Ltden_US
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-Type Natriuretic Peptideen_US
dc.subjectMesenteric Ischaemiaen_US
dc.subjectIschaemia Durationen_US
dc.titleDiagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemiaen_US
dc.titleDiagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia
dc.typeArticleen_US

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