Levels of neopterin and other inflammatory markers in obese and non-obese patients with polycystic ovary syndrome
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
International Scientific Literature Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: We aimed to measure the levels of inflammatory markers and neopterin in obese and non-obese patients with PCOS by using 2 separate control groups with matching body mass index (BMI). Material/Methods: A total of 60 women of reproductive age with (n=30) and without (n=30) PCOS were included in this study. Based on their BMI, patients with PCOS were divided into 2 groups as obese (n=15) and non-obese (n=15) PCOS groups. In addition, 2 BMI-matched control groups were formed. Neopterin, tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6), C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (N/L ratio), and vitamin B12 were assessed by complete blood count. Results: No significant difference was found between patients with PCOS and control subjects in neopterin, IL-6, TNF-?, and CRP levels. However, N/L ratio levels were significantly higher (p 0.045) and vitamin B12 levels were significantly lower (p 0.033) in patients with PCOS compared to control subjects. No statistically significant difference was found between obese and non-obese patients with PCOS and control subjects in neopterin, IL-6, TNF-?, and N/L ratio levels. However, CRP levels were significantly higher in obese patients with PCOS compared to obese control subjects (p 0.007). Conclusions: It can be concluded that inflammatory activity is increased in patients with PCOS, can lead to an increased risk for atherosclerosis, and this increase is not caused by obesity but rather by the polycystic ovary syndrome itself. However, studies with larger sample sizes are needed in this area.
Açıklama
Anahtar Kelimeler
Abdominal, Inflammation, Obesity, Polycystic ovary syndrome
Kaynak
Medical Science Monitor
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
21
Sayı
Künye
Ağaçayak, E., Tunç, S. Y., Sak, S., Başaranoğlu, S., Yüksel, H., Turgut, A. ve diğerleri. (2015). Levels of neopterin and other inflammatory markers in obese and non-obese patients with polycystic ovary syndrome. Medical Science Monitor, 21, 2446-2455.
