Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study

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dc.authorid0000-0002-8433-3480en_US
dc.authorid0000-0002-7925-8121en_US
dc.authorid0000-0002-2150-6866en_US
dc.authorid0000-0001-7657-3065en_US
dc.contributor.authorGündoǧan, Kürşat
dc.contributor.authorŞahin, Gülşah Güneş
dc.contributor.authorErgül, Serap Şahin
dc.contributor.authorÖzer, Nurhayat Tuğra
dc.contributor.authorTemel, Şahin
dc.contributor.authorAkbaş, Türkay
dc.contributor.authorAydın, Emre
dc.date.accessioned2023-10-26T11:20:51Z
dc.date.available2023-10-26T11:20:51Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractBackground/Objectives: Thiamine plays a pivotal role in energy metabolism. The aim of the study was to determine serial whole blood TPP concentrations in critically ill patients receiving chronic diuretic treatment before ICU admission and to correlate TPP levels with clinically determined serum phosphorus concentrations. Subjects/Methods: This observational study was performed in 15 medical ICUs. Serial whole blood TPP concentrations were measured by HPLC at baseline and at days 2, 5 and 10 after ICU admission. Results: A total of 221 participants were included. Of these, 18% demonstrated low TPP concentrations upon admission to the ICU, while 26% of participants demonstrated low levels at some point during the 10-day study period. Hypophosphatemia was detected in 30% of participants at some point during the 10-day period of observation. TPP levels were significantly and positively correlated with serum phosphorus levels at each time point (P < 0.05 for all). Conclusions: Our results show that 18% of these critically ill patients exhibited low whole blood TPP concentrations on ICU admission and 26% had low levels during the initial 10 ICU days, respectively. The modest correlation between TPP and phosphorus concentrations suggests a possible association due to a refeeding effect in ICU patients requiring chronic diuretic therapy.en_US
dc.description.sponsorshipErciyes University Scientific Research Committee THD-2020- 10295en_US
dc.description.sponsorshipTurkish Society of Clinical Enteral & Parenteral Nutrition (KEPAN)
dc.identifier.citationGündoğan, K., Şahin, G. G., Ergül, S. Ş., Özer, N. T., Temel, Ş., Akbaş, T. ve diğerleri. (2023). Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study. Journal of Critical Care, (77), 1-6.en_US
dc.identifier.doi10.1016/j.jcrc.2023.154326
dc.identifier.endpage6en_US
dc.identifier.issn0883-9441
dc.identifier.issue77en_US
dc.identifier.pmid37186999
dc.identifier.scopus2-s2.0-85159090175
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0883944123000758?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12956
dc.identifier.wosWOS:001010698900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Emre
dc.language.isoenen_US
dc.publisherW.B. Saundersen_US
dc.relation.ispartofJournal of Critical Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCritical illnessen_US
dc.subjectDiureticsen_US
dc.subjectRefeeding syndromeen_US
dc.subjectThiamineen_US
dc.titleEvaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective studyen_US
dc.titleEvaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study
dc.typeArticleen_US

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