Examining the levels of BDNF and cortisol in children and adolescent victims of sexual abuse-a preliminary study

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dc.contributor.authorSimsek, Seref
dc.contributor.authorYuksel, Tugba
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorUysal, Cem
dc.contributor.authorAlaca, Rumeysa
dc.date.accessioned2024-04-24T16:11:08Z
dc.date.available2024-04-24T16:11:08Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Previous reports have suggested the biological and psychological effects of trauma induced by cortisol and brain-derived neurotrophic factor (BDNF). The present study compared the levels of BDNF, cortisol, and adrenocorticotropic hormone (ACTH) in children and adolescent victims of sexual abuse to those without a trauma history. Methods: The study was conducted in the Department of Child Psychiatry at Dicle University. The study included 44 children (M/F: 12/32) aged between 8 and 17 years who experienced sexual abuse with 42 age-and gender-matched children who did not have a history of trauma. Cortisol, ACTH, and BDNF levels were measured using ELISA. Results: Cortisol levels were higher and BDNF levels were significantly lower in the victims of sexual abuse compared to the control group. The mean time that elapsed from the initial sexual abuse occurrence until the date of examination was 22.7+/-21.7 months. The evaluation of the relationship between this time span and cortisol levels revealed that cortisol levels decreased with increasing time after trauma. Cortisol and BDNF levels were lower in the victims who experienced multiple sexual assaults. Conclusions: The results of the present study suggest that cortisol and BDNF could be biological molecular mediators of the effects of trauma on biological and psychological systems. This is the first report on the effects of cortisol and BDNF induced trauma in child and adolescent victims of sexual abuse. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.comppsych.2015.04.013
dc.identifier.endpage27en_US
dc.identifier.issn0010-440X
dc.identifier.issn1532-8384
dc.identifier.pmid25982069
dc.identifier.scopus2-s2.0-84943663519
dc.identifier.scopusqualityQ1
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.comppsych.2015.04.013
dc.identifier.urihttps://hdl.handle.net/11468/15283
dc.identifier.volume61en_US
dc.identifier.wosWOS:000357908800004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofComprehensive Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleExamining the levels of BDNF and cortisol in children and adolescent victims of sexual abuse-a preliminary studyen_US
dc.titleExamining the levels of BDNF and cortisol in children and adolescent victims of sexual abuse-a preliminary study
dc.typeArticleen_US

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