The protective role of caffeic acid phenethyl ester against streptomycin ototoxicity

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dc.contributor.authorBakir, Salih
dc.contributor.authorOzbay, Musa
dc.contributor.authorGun, Ramazan
dc.contributor.authorYorgancilar, Ediz
dc.contributor.authorKinis, Vefa
dc.contributor.authorKeles, Aysenur
dc.contributor.authorAbakay, Abdurrahman
dc.date.accessioned2024-04-24T16:10:47Z
dc.date.available2024-04-24T16:10:47Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this experimental study was to investigate the efficacy of caffeic acid phenethyl ester (CAPE) in the prevention of streptomycin-induced ototoxicity. Materials and Methods: Thirty-two adult Wistar albino rats were divided into 4 groups: control (n = 8), streptomycin (n = 8), CAPE (n = 8), and streptomycin + CAPE (n = 8). Rats were tested with distortion product otoacoustic emissions (DPOAEs) before drug administration. The animals in all groups were killed under general anesthesia on the 45th day following last DPOAE measurements. Hearing results were analyzed statistically to determine differences in amplitudes of DPOA E. Also, the cochleas of each rat were evaluated by histopathological and immunohistochemical examination. Results: Significant difference was not observed in cochlear hair cells in the control and CAPE groups. In the streptomycin group, severe degeneration of hair cells and increased apoptotic cells were observed. In the streptomycin + CAPE group, although some deteriorations were observed, hair cells were mostly preserved. The DPgram of the streptomycin and streptomycin + CAPE groups was significantly deteriorated (P < .05). The analysis of the DPgram results revealed statistically significant differences between the groups of streptomycin and streptomycin + CAPE (P < .05). Conclusions: Caffeic acid phenethyl ester treatment attenuated hair cells injury in the inner ear, possibly via its antioxidant effect. Prophylactic administration of CAPE for streptomycin ototoxicity ameliorated hearing deterioration in rats. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipDicle University Research fund [10-TF-63]en_US
dc.description.sponsorshipThis experimental study was supported by a grant from the Dicle University Research fund under the project number 10-TF-63.en_US
dc.identifier.doi10.1016/j.amjoto.2012.07.003
dc.identifier.endpage21en_US
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue1en_US
dc.identifier.pmid22964505
dc.identifier.scopus2-s2.0-84870942461
dc.identifier.scopusqualityQ1
dc.identifier.startpage16en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2012.07.003
dc.identifier.urihttps://hdl.handle.net/11468/15105
dc.identifier.volume34en_US
dc.identifier.wosWOS:000312571200004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe protective role of caffeic acid phenethyl ester against streptomycin ototoxicityen_US
dc.titleThe protective role of caffeic acid phenethyl ester against streptomycin ototoxicity
dc.typeArticleen_US

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