Relationship of the HLA-DRB1 alleles and seropositivity, anti-MCV, functional status and radiological damage in Turkish patients with rheumatoid arthritis

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dc.contributor.authorSariyildiz, Mustafa Akif
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorCetincakmak, Mehmet Guli
dc.contributor.authorYildiz, Ismail
dc.contributor.authorNas, Kemal
dc.contributor.authorCevik, Remzi
dc.date.accessioned2024-04-24T17:20:43Z
dc.date.available2024-04-24T17:20:43Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVES: The HLA-DRB1 gene plays an important role in the genetic predisposition to rheumatoid arthritis. The anti-citrullinated protein antibody (ACPA) is known to be associated with the susceptibility to rheumatoid arthritis (RA), as well as the severity of the disease. The aim of this study is to determine the HLA genes that are associated with the severity of the RA measured by seropositivity, functional status, radiological damage and the anti-modified citrullinated vimentin (MCV) levels. MATERIAL AND METHOD: Ninety-six patients diagnosed with rheumatoid arthritis and a control group consisting of 84 healthy individuals were enrolled in the study. The HLA-DRB1 type and subtypes were specified using the polymerase chain reaction with sequence-specific primers (PCR-SSP). The association of the HLA-DRB1 type and subtypes with seropositivity, anti-MCV levels, functional status and anatomical joint damage were explored using the modified Larsen scoring method. RESULTS: The DRB1*01, DRB1*04, DRB1*07, DRB1*10, DRB1*11 and DRB1*15 alleles were found to be related with higher anti-MCV levels (p < 0.05). The DRB1*11 type and the DRB1*1001 subtype were observed to be associated with poor functional status (Stages 3-4). The DRB1*0801 subtype was associated with lower anti MCV levels (OR = 8.35, p = 0.02). DRB1*04 type and DRB1*0405 subtypes were related with radiological damage (OR = 0.52 and 0.25; p = 0.04 and 0.03, respectively). No significant relationship was observed between the RF seropositivity and the HLA-DRB1 alleles. CONCLUSION: This study revealed the association between the HLA alleles and seropositivity, functional status, anti-MCV levels and radiological damage in patients in the Southeast Anatolian region of Turkey.en_US
dc.identifier.doi10.3233/BMR-2012-00351
dc.identifier.endpage70en_US
dc.identifier.issn1053-8127
dc.identifier.issue1en_US
dc.identifier.pmid23411650
dc.identifier.scopus2-s2.0-84873205430
dc.identifier.scopusqualityQ2
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.3233/BMR-2012-00351
dc.identifier.urihttps://hdl.handle.net/11468/19211
dc.identifier.volume26en_US
dc.identifier.wosWOS:000314348300009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofJournal of Back and Musculoskeletal Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectHla-Drb1en_US
dc.subjectSeropositivityen_US
dc.subjectFunctional Statusen_US
dc.subjectAnti-Mcven_US
dc.subjectRadiological Damageen_US
dc.titleRelationship of the HLA-DRB1 alleles and seropositivity, anti-MCV, functional status and radiological damage in Turkish patients with rheumatoid arthritisen_US
dc.titleRelationship of the HLA-DRB1 alleles and seropositivity, anti-MCV, functional status and radiological damage in Turkish patients with rheumatoid arthritis
dc.typeArticleen_US

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