LC-HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus Brachystachys DC

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dc.authoridMATARACI KARA, EMEL/0000-0002-4428-5066
dc.contributor.authorErsoy, Ezgi
dc.contributor.authorBoga, Mehmet
dc.contributor.authorKaplan, Alevcan
dc.contributor.authorKara, Emel Mataraci
dc.contributor.authorOzkan, Esra Eroglu
dc.contributor.authorKayiran, Serpil Demirci
dc.date.accessioned2025-02-22T14:09:11Z
dc.date.available2025-02-22T14:09:11Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractAstragalus species are ubiquitous in the pharmacopeia of numerous countries, signifying their widespread medicinal applications. T & uuml;rkiye is esteemed as one of the principal epicenters of diversity for this genus with 483 taxa, and many of these plants have been traditionally utilized for diseases including coughing, diabetes, cardiovascular disorders, and aches. Although there is a considerable body of chemical and biological research available on several Astragalus species, studies focusing on Astragalus brachystachys DC are exceedingly rare. In this context, This study provides the first comprehensive report on this medicinal plant the chemical constituents and biological activities of an important medicinal plant, Astragalus brachystachys DC. The aerial part samples were collected from Adana, T & uuml;rkiye, and an ethanol extract was prepared with these parts. The secondary metabolites of the extract were determined by an LC-HRMS analysis. The LC-HRMS analysis showed the presence of 39 different constituents, hyperoside (303.419 +/- 10.50 mu g/g extract), p-coumaric acid (256.975 +/- 8.51 mu g/g extract), and rutin (72.684 +/- 2.23 mu g/g extract) were determined as major compounds in the aerial parts ethanol extract. Attributed to its high total phenolic (58.53 +/- 1.30 mu g PEs/mg extract) and total flavonoid content (29.98 +/- 0.83 mu g QEs/mg extract), the extract demonstrated strong antioxidant activity according to three different assays namely DPPH free (IC50: 33.08 +/- 0.61 mu g/mL), and ABTS cation radical scavenging (IC50: 15.39 +/- 0.72 mu g/mL) and CUPRAC activity (A0.5: 36.25 +/- 0.28 mu g/mL) methods. In vitro assays showed that cholinesterase inhibitory activity results were found to be exceptional with 85.95 +/- 0.52 % inhibition on acetylcholinesterase and 66.32 +/- 1.33 % inhibition on butyrylcholinesterase at 200 mu g/mL. Regarding antimicrobial properties, Astragalus brachystachys DC extract was found to be effective against Enterococcus faecalis with a MIC value of 39.06 mu g/mL.en_US
dc.identifier.doi10.1002/cbdv.202401853
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid39400994en_US
dc.identifier.scopus2-s2.0-85209115534en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202401853
dc.identifier.urihttps://hdl.handle.net/11468/29824
dc.identifier.wosWOS:001356839900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectAstragalus brachystachysen_US
dc.subjectLC-HRMSen_US
dc.subjectAntioxidant activityen_US
dc.subjectCholinesterase inhibitionen_US
dc.titleLC-HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus Brachystachys DCen_US
dc.typeArticleen_US

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