Atherosclerosis and the role of immune cells

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Tarih

2015

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Baishideng Publishing Group Inc

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-alpha and beta are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-gamma and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.

Açıklama

Anahtar Kelimeler

Atherosclerosis, Inflammatory Cytokines, Pro-Inflammatory Mediators, Immune Cells, Adhesion Molecules

Kaynak

World Journal of Clinical Cases

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

3

Sayı

4

Künye