A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats

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dc.contributor.authorDemir, F.
dc.contributor.authorGuzel, A.
dc.contributor.authorKati, C.
dc.contributor.authorKaradeniz, C.
dc.contributor.authorAkdemir, U.
dc.contributor.authorOkuyucu, A.
dc.contributor.authorGacar, A.
dc.date.accessioned2024-04-24T17:18:07Z
dc.date.available2024-04-24T17:18:07Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractCardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n = 7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg.kg(-1).day(-1)), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-alpha) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-alpha levels were elevated after contusion (P = 0.001 and P = 0.001). Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P = 0.001 and P = 0.011, respectively). Histopathological degeneration and necrosis scores were statistically lower in the methylprednisolone and quercetin combination group compared to the group treated only with methylprednisolone (P = 0.017 and P = 0.007, respectively). However, only degeneration scores were lower in the combination therapy group compared to the group treated only with quercetin (P = 0.017). Inducible nitric oxide synthase positivity scores were decreased in all treatment groups compared to the untreated groups (P = 0.097, P = 0.026, and P = 0.004, respectively). We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion.en_US
dc.identifier.doi10.1590/1414-431X20144021
dc.identifier.endpage772en_US
dc.identifier.issn0100-879X
dc.identifier.issn1678-4510
dc.identifier.issue9en_US
dc.identifier.pmid25098616
dc.identifier.scopus2-s2.0-84906489548
dc.identifier.scopusqualityQ1
dc.identifier.startpage766en_US
dc.identifier.urihttps://doi.org/10.1590/1414-431X20144021
dc.identifier.urihttps://hdl.handle.net/11468/18621
dc.identifier.volume47en_US
dc.identifier.wosWOS:000340836500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlunt Chest Traumaen_US
dc.subjectCardiac Contusionen_US
dc.subjectQuercetinen_US
dc.subjectMethylprednisoloneen_US
dc.subjectInosen_US
dc.titleA combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in ratsen_US
dc.titleA combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats
dc.typeArticleen_US

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