Clinical and cranial magnetic resonance imaging (MRI) findings of 21 patients with serious hyperbilirubinemia

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dc.contributor.authorKatar, Selahattin
dc.contributor.authorAkay, Hatice Ozturkmen
dc.contributor.authorTaskesen, Mustafa
dc.contributor.authorDevecioglu, Celal
dc.date.accessioned2024-04-24T17:14:36Z
dc.date.available2024-04-24T17:14:36Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aims to compare neurological examination and cranial magnetic resonance imaging (MRI) findings in patients with serious hyperbilirubinemia. Twenty-one serious hyperbiluribinemic term neonates (6 girls, 15 boys) who underwent exchange transfusions were included in the study. Neurological examination findings, body weight, age at admission, blood culture, urine culture, urine analysis, C-reactive protein, thyroxine, thyroid-stimulating hormone, total and indirect bilirubin levels, causes of hyperbilirubinemia (blood group typing, glucose-6-phosphate dehydrogenase, blood smear, tandem mass), treatment and duration of follow-up, auditory test results, and cranial MRI findings were evaluated. All patients were term neonates with an average body weight of 2943 +/- 533 g. The mean age at admission was 4.47 +/- 2.22 days, and the mean bilirubin level was 35.0 +/- 10.8 mg/dL. Exchange transfusion was performed once in all, except 4 patients who needed 2 transfusions. Kernicterus findings were found in 76% of patients on neurological examination, and cranial MRI detected a pathological finding in 71% of patients. In 2 patients, cranial MRI showed kernicterus findings, despite normal neurological examination. In contrast, in 3 patients, despite kernicterus findings in neurological examination, cranial MRI was normal. Although cranial MRI has an important place in the diagnosis of kernicterus, it does not always correlate with clinical findings. We believe that studies with larger series are warranted.en_US
dc.identifier.doi10.1177/0883073807309780
dc.identifier.endpage417en_US
dc.identifier.issn0883-0738
dc.identifier.issue4en_US
dc.identifier.pmid18182649
dc.identifier.scopus2-s2.0-41549120207
dc.identifier.scopusqualityQ1
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1177/0883073807309780
dc.identifier.urihttps://hdl.handle.net/11468/18088
dc.identifier.volume23en_US
dc.identifier.wosWOS:000254550900008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Child Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperhilirubinemiaen_US
dc.subjectKernicterusen_US
dc.titleClinical and cranial magnetic resonance imaging (MRI) findings of 21 patients with serious hyperbilirubinemiaen_US
dc.titleClinical and cranial magnetic resonance imaging (MRI) findings of 21 patients with serious hyperbilirubinemia
dc.typeArticleen_US

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