Distinction of hypertriglyceridemic waist phenotype from simple abdominal obesity: interaction with sex hormone-binding globulin levels to confer high coronary risk

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dc.contributor.authorKaragoz, Ahmet
dc.contributor.authorOnat, Altan
dc.contributor.authorAydin, Mesut
dc.contributor.authorCan, Gunay
dc.contributor.authorSimsek, Baris
dc.contributor.authorYuksel, Murat
dc.date.accessioned2024-04-24T16:24:19Z
dc.date.available2024-04-24T16:24:19Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The associations of total testosterone (TT) and sex hormone-binding globulin (SHBG) with the hypertriglyceridemic waist (HtgW) phenotype and coronary heart disease (CHD) risk have scarcely been examined. We explored such cardiometabolic risk mediations in middle-aged adults. Methods: Participants (n = 1924) in a population-based study were studied by forming categories consisting of abdominal obesity, hypertriglyceridemia, both (HtgW), or none ('healthy'). Cardiometabolic risk was prospectively analyzed (mean follow-up 5.7 years). Results: With reference to the healthy group, SHBG values in HtgW were significantly lower, alike serum HDL-cholesterol. ApolipoproteinB-containing lipoproteins, fasting glucose and complement C3 levels, inverse to lipoprotein[Lp](a) especially in female participants with HtgW phenotype compared with those in the 'healthy' category, suggested the operation of aggregation to Lp(a). Multivariable Cox regression analysis in a model comprising age, waist circumference and systolic blood pressure showed significant protection by SHBG against incident diabetes which tended to be so with TT in men. Sex hormones were not associated with risk of incident CHD or MetS. In another multivariable model, compared to the ` healthy' and the hypertriglyceridemia categories, dichotomized high and, in females, low SHBG values within the HtgW category, positively predicted CHD at significant over 2-fold relative risks. Conclusion: HtgW phenotype distinguishes itself from the (virtually neutral) simple abdominal obesity in independently conferring high CHD risk when elevated or reduced SHBG levels interact. Underlying operation of Lp(a) aggregation is suggested.en_US
dc.description.sponsorshipautomotive firm TOFAS, Istanbul, Turkeyen_US
dc.description.sponsorshipFinancial support for this study was provided by the automotive firm TOFAS, Istanbul, Turkey.en_US
dc.identifier.doi10.1080/00325481.2017.1261608
dc.identifier.endpage295en_US
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue2en_US
dc.identifier.pmid27846754
dc.identifier.scopus2-s2.0-84997831556
dc.identifier.scopusqualityQ1
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1080/00325481.2017.1261608
dc.identifier.urihttps://hdl.handle.net/11468/16653
dc.identifier.volume129en_US
dc.identifier.wosWOS:000396796800015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPostgraduate Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Heart Disease Risken_US
dc.subjectHypertriglyceridemic Waist Phenotypeen_US
dc.subjectLipoprotein(A)en_US
dc.subjectSex Hormone-Binding Globulinen_US
dc.subjectTestosteroneen_US
dc.titleDistinction of hypertriglyceridemic waist phenotype from simple abdominal obesity: interaction with sex hormone-binding globulin levels to confer high coronary risken_US
dc.titleDistinction of hypertriglyceridemic waist phenotype from simple abdominal obesity: interaction with sex hormone-binding globulin levels to confer high coronary risk
dc.typeArticleen_US

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