What does quantitative HBsAg level mean in chronic hepatitis D infection?

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dc.contributor.authorEbik, Berat
dc.contributor.authorCangul, M. Sadik
dc.contributor.authorYalcin, Kendal
dc.date.accessioned2024-04-24T17:08:21Z
dc.date.available2024-04-24T17:08:21Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectiveIn hepatitis delta virus (HDV) infection, which is an important etiological cause of chronic liver disease, the relationship between serum quantitative HBsAg level and fibrosis and histological activity was investigated. MethodsBetween 2014 and 2020, 98 patients with chronic HDV infection (53 noncirrhotic, 45 cirrhotic) participated in this prospectively designed study. Quantitative HBsAg levels of the patients were measured and their relationship with the stage of chronic liver disease was compared with histological activity index (HAI), fibrosis score and HDV RNA, model for end-stage liver disease score and other biochemical parameters. ResultsAll patients were infected with genotype 1 (100%). HBeAg was positive in 8 (8.1%) of the patients. A correlation was found between quantitative HBsAg level and HDV RNA level in patients with both cirrhotic (r = 0.568; P < 0.001) and noncirrhotic (r = 0.644; P < 0.001) HDV infection. Alanine transaminase (P = 0.001; r = 0.495) and aspartate transaminase (P = 0.001; r = 0.511) levels correlated with quantitative HBsAg levels, more prominently in noncirrhotic patients. There was a correlation between quantitative HBsAg level and histological activity index (HAI) in patients with noncirrhotic HDV infection (P < 0.001; r = 0.664). In receiver operating characteristic analysis, both quantitative HBsAg (for cutoff: 1000; sensitivity 76%; specificity 17%; P = 0.335) and HDV RNA (for cutoff: 100000; sensitivity 2%; specificity 98%; P = 0.096) were not predictive markers for cirrhosis. ConclusionQuantitative HBsAg level can be evaluated as an indicator of viral replication and histological activity in patients with chronic delta hepatitis without cirrhosis. We think that quantitative HBsAg level will be useful in the management of chronic HDV infection, especially in noncirrhotic patients.en_US
dc.identifier.doi10.1097/MEG.0000000000002489
dc.identifier.endpage326en_US
dc.identifier.issn0954-691X
dc.identifier.issn1473-5687
dc.identifier.issue3en_US
dc.identifier.pmid36708303
dc.identifier.scopus2-s2.0-85147091312
dc.identifier.scopusqualityQ2
dc.identifier.startpage320en_US
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000002489
dc.identifier.urihttps://hdl.handle.net/11468/17312
dc.identifier.volume35en_US
dc.identifier.wosWOS:000921038100013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Delta Hepatitis Infectionen_US
dc.subjectFibrosisen_US
dc.subjectHistological Activityen_US
dc.subjectImportanceen_US
dc.subjectQuantitative Hbsag Levelen_US
dc.titleWhat does quantitative HBsAg level mean in chronic hepatitis D infection?en_US
dc.titleWhat does quantitative HBsAg level mean in chronic hepatitis D infection?
dc.typeArticleen_US

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