Synthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes

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dc.contributor.authorSolmaz, Ummuhan
dc.contributor.authorGumus, Ilkay
dc.contributor.authorBinzet, Gun
dc.contributor.authorCelik, Omer
dc.contributor.authorBalci, Gulten Kavak
dc.contributor.authorDogen, Aylin
dc.contributor.authorArslan, Hakan
dc.date.accessioned2024-04-24T16:24:25Z
dc.date.available2024-04-24T16:24:25Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractN, N-Di-R-N'-(4-chlorobenzoyl) thiourea (Di-R: diethyl, di-n-propyl, din-butyl and diphenyl) ligands (HL1-4) and their Pt(II) complexes (cis[ Pt(L1-4-S, O)(2)]) have been synthesized and structurally characterized by elemental analyses, FT-IR and NMR spectroscopy. HL2 ligand and cis-[ Pt(L-4-S, O)(2)] metal complex have been also characterized by a single-crystal X-ray diffraction study. HL2, C14H19ClN2OS, crystallizes in the monoclinic space group P2(1)/n (no. 14), with Z = 4, and unit cell parameters, a = 11.1405(16) angstrom, b = 9.7015(12) angstrom, c = 14.790(2) angstrom, beta = 106.547(7)degrees. The cis-[ Pt(L-4-S, O)(2)], C40H28Cl2N4O2PtS2 : triclinic, space group P-1 (no. 2), a = 8.9919(3) angstrom, b = 14.7159(6) angstrom, c = 15.7954(6) angstrom, a = 113.9317(18)degrees, beta = 97.4490(18)degrees, and. = 105.0492(16)degrees. Single crystal analysis of complex, cis-[ Pt(L1-4-S, O)(2)], revealed that a square planar coordination geometry is formed around the platinum atom by two sulfur and two oxygen atoms of the related ligands, which are in a cis configuration. In addition, the thiourea derivative ligands and their complexes were evaluated for both their in-vitro antibacterial and antifungal activity. The results have been reported, explained, and compared with fluconazole and ampicillin, used as reference drugs.en_US
dc.description.sponsorshipMersin University Research Fund [2015-AP4-1162]en_US
dc.description.sponsorshipThis work was supported by the Mersin University Research Fund [Project number 2015-AP4-1162].en_US
dc.identifier.doi10.1080/00958972.2018.1427233
dc.identifier.endpage218en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85041621649
dc.identifier.scopusqualityQ3
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2018.1427233
dc.identifier.urihttps://hdl.handle.net/11468/16707
dc.identifier.volume71en_US
dc.identifier.wosWOS:000426924900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBenzoyl Thioureaen_US
dc.subjectPlatinum Complexen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectIntermolecular Interactionen_US
dc.subjectCrystal Structure Analysisen_US
dc.titleSynthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexesen_US
dc.titleSynthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes
dc.typeArticleen_US

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