Synthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes
[ X ]
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
N, N-Di-R-N'-(4-chlorobenzoyl) thiourea (Di-R: diethyl, di-n-propyl, din-butyl and diphenyl) ligands (HL1-4) and their Pt(II) complexes (cis[ Pt(L1-4-S, O)(2)]) have been synthesized and structurally characterized by elemental analyses, FT-IR and NMR spectroscopy. HL2 ligand and cis-[ Pt(L-4-S, O)(2)] metal complex have been also characterized by a single-crystal X-ray diffraction study. HL2, C14H19ClN2OS, crystallizes in the monoclinic space group P2(1)/n (no. 14), with Z = 4, and unit cell parameters, a = 11.1405(16) angstrom, b = 9.7015(12) angstrom, c = 14.790(2) angstrom, beta = 106.547(7)degrees. The cis-[ Pt(L-4-S, O)(2)], C40H28Cl2N4O2PtS2 : triclinic, space group P-1 (no. 2), a = 8.9919(3) angstrom, b = 14.7159(6) angstrom, c = 15.7954(6) angstrom, a = 113.9317(18)degrees, beta = 97.4490(18)degrees, and. = 105.0492(16)degrees. Single crystal analysis of complex, cis-[ Pt(L1-4-S, O)(2)], revealed that a square planar coordination geometry is formed around the platinum atom by two sulfur and two oxygen atoms of the related ligands, which are in a cis configuration. In addition, the thiourea derivative ligands and their complexes were evaluated for both their in-vitro antibacterial and antifungal activity. The results have been reported, explained, and compared with fluconazole and ampicillin, used as reference drugs.
Açıklama
Anahtar Kelimeler
Benzoyl Thiourea, Platinum Complex, Antimicrobial Activity, Intermolecular Interaction, Crystal Structure Analysis
Kaynak
Journal of Coordination Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
71
Sayı
2
