Di-, and triterpenoids isolation and LC-MS analysis of salvia marashica extracts with bioactivity studies

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dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorAydın, Sibel Kıran
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorErol, Ebru
dc.contributor.authorToraman, Gülbahar O. Alim
dc.contributor.authorSaygı, Tuba Kusman
dc.contributor.authorHalfon, Belkıs
dc.contributor.authorTopçu, Gülaçtı
dc.date.accessioned2021-07-01T12:34:05Z
dc.date.available2021-07-01T12:34:05Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.descriptionWOS:000658306500004
dc.description.abstractAbstract: In this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salvia marashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of these extracts were determined as pyrocatechol equivalent and total flavonoids as quercetin equivalent. Antioxidant activity was determined by four complementary methods including inhibition of lipid peroxidation (by βcarotene color expression), DPPH free radical scavenging activity, ABTS cation radical scavenging activity and CUPRAC methods. Anticholinesterase activity of the extracts was investigated by the Ellman method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Viability and cytotoxic activity tests were carried out on the fibroblast L929 cells and cytotoxic A549 lung cancer cells, respectively. The triterpenoids and diterpenoids constitute the major secondary metabolites of the S. marashica acetone and methanol extracts isolated by chromatographic methods. Their structures were determined based on spectroscopic methods, namely NMR and mass analyses. Ten terpenoids were obtained from either acetone or methanol extracts of the S. marashica. Seven of them were triterpenoids, elucidated as lupeol, lupeol-3-acetate, lup-12, 20(29)-diene, lup-20(29)-ene, α-amyrin-tetracosanoate, oleanolic acid and ursolic acid besides a steroid β-sitosterol. Two abietane diterpenes, abieta-8,11,13-triene (1) and 18-acetoxymethylene-abieta-8,11,13-triene (2), were obtained from the acetone extract which were isolated from a Salvia species for the first time in the present study. The methanol extract was found to be very rich in rosmarinic acid determined by LC-MS/MS analysis.en_US
dc.identifier.citationAydın, S.K., Ertaş, A., Boğa, M., Erol, E., Toraman, G.O.A., Saygı, T.K. ve diğerleri. (2021). Di-, and triterpenoids isolation and LC-MS analysis of salvia marashica extracts with bioactivity studies. Records of Natural Products, 15(6), 463-475.en_US
dc.identifier.doi10.25135/rnp.251.21.03.2003
dc.identifier.endpage475en_US
dc.identifier.issn1307-6167
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85112071993
dc.identifier.scopusqualityQ2
dc.identifier.startpage463en_US
dc.identifier.urihttps://www.acgpubs.org/doc/20210528171104A3-251-RNP-2103-2003.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7193
dc.identifier.volume15en_US
dc.identifier.wosWOS:000658306500004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSalvia marashicaen_US
dc.subjectTerpenoidsen_US
dc.subjectFlavonoidsen_US
dc.subjectNMRen_US
dc.subjectLC-MS/MSen_US
dc.subjectBioactivityen_US
dc.titleDi-, and triterpenoids isolation and LC-MS analysis of salvia marashica extracts with bioactivity studiesen_US
dc.titleDi-, and triterpenoids isolation and LC-MS analysis of salvia marashica extracts with bioactivity studies
dc.typeArticleen_US

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