A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals

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dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorYıldıztugay, Evren
dc.contributor.authorLobine, Devina
dc.contributor.authorOuelbani, Rayene
dc.contributor.authorBensari, Souheir
dc.contributor.authorAk, Güneş
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorGallo, Monica
dc.contributor.authorMontesano, Domenico
dc.date.accessioned2022-06-16T08:11:50Z
dc.date.available2022-06-16T08:11:50Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.descriptionWOS:000623164500003
dc.descriptionPMID: 33648291
dc.description.abstractGeophytes are gaining interest as sources of natural ingredients in nutraceutical and pharmaceutical area. In this sense, six bulbous plant species from Turkey are investigated, namely Hyacinthella campanulata K.Perss. & Wendelbo, Muscari neglectum Guss. ex Ten., Tulipa humilis herb., Iris stenophylla Hausskn. ex Baker, Galanthus elwesii Hook. f. and Crocus danfordiae Maw. with the aim to highlight their chemical compositions and biological properties. Polyphenolic profiles of the different plant parts (flower, bulb and leaf) of the six genotypes were evaluated using colorimetric methods as well LC-MS/MS. The antioxidant properties and enzymes inhibitory potential (alpha-amylase, alpha-glucosidase, tyrosinase and cholinesterases) of the extracts were determined. Overall, highest total phenolic content and total flavonoid content were observed in the leaf extracts of the studied species, except for M. neglectum (flower extract) and T. humilis (flower extract). LC-MS/MS analysis revealed the abundance of some phenolic compounds including quinic acid, hesperidin and chlorogenic acid in selective extracts. The extracts showed significant antioxidant potentials, with leaf extract of the I. stenophylla being more potent, which is linked to its high phenolic contents. All the extracts displayed notable anti-acetylcholinesterase (1.77 - 2.53 mg GALAE/g) and tyrosinase (54.9-67.20 mg KAE/g). Selective extracts have showed activity against butyrylcholinesterase, with bulb extract of M. neglectum (2.99 mg GALAE/g), I. stenophylla (2.53 mg GALAE/g) and G. elwesii (2.52 mg GALAE/g) showing highest activity. Modest activity was observed against alpha-amylase and alpha-glucosidase. The experimental data gathered herein is the first report on the phytochemical and biological attributes of these bulbous plant species which project them as potential sources of biologically active compounds for phytomedicines and nutraceuticals development.en_US
dc.identifier.citationMahomoodally, M.F., Zengin, G., Sinan, K.I., Yıldıztugay, E., Lobine, D., Ouelbani, R. ve diğerleri. (2021). A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals. Food Research International, 140, 1-9.en_US
dc.identifier.doi10.1016/j.foodres.2020.110068
dc.identifier.endpage9en_US
dc.identifier.issn0963-9969
dc.identifier.issn1873-7145
dc.identifier.pmid33648291
dc.identifier.scopus2-s2.0-85098936366
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0963996920310930?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/10001
dc.identifier.volume140en_US
dc.identifier.wosWOS:000623164500003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofFood Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhenolicen_US
dc.subjectAntioxidanten_US
dc.subjectCholinesteraseen_US
dc.subjectAmylaseen_US
dc.subjectPhytochemicalen_US
dc.subjectNutraceuticalen_US
dc.titleA comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticalsen_US
dc.titleA comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals
dc.typeArticleen_US

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