Prognostic Factors in Gastrointestinal Stromal Tumors: Multicenter Experience of 333 Cases from Turkey

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dc.contributor.authorSeker, Mesut
dc.contributor.authorSevinc, Alper
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorCihan, Sener
dc.contributor.authorKaplan, Mehmet Ali
dc.contributor.authorGokdurnali, Ayse
dc.contributor.authorDane, Faysal
dc.date.accessioned2024-04-24T17:28:02Z
dc.date.available2024-04-24T17:28:02Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground/Aims: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. In an attempt to survey the approximate incidence, clinicopathological characteristics, and immunophenotypic features of GISTs in Turkey, we conducted a clinicopathological and immunohistochemical analysis of GISTs. Methodology: Three hundred and thirty-three patients with GIST from nine institutions in Turkey were retrospectively evaluated. Results: Between January 2001 and March 2011, a total of 333 patients with GISTs were included; of these, 204 (61.2%) were male and 129 (38.8%) were female. The median age was 55 years (range; 22402 years). At the median follow-up of 26 months (range; 4-166 months), the 1-, 3- and 5-year OS rates of the 333 patients were 96.9%, 85.8% and 78.5%, respectively. The 5-year DFS rate was 40%. The 5-year OS rate and median OS time for the patients with R-0 resection were significantly higher than for patients with metastatic diseases (79.7 vs. 75.7% and not reached vs. 115 months, respectively, p=0.04). Conclusion: Although our results should be confirmed by prospective studies, we believe that they contribute to the literature because the study included both resectable and metastatic or unresectable GIST patients and multicenter findings from Turkey.en_US
dc.identifier.doi10.5754/hge11666
dc.identifier.endpage775en_US
dc.identifier.issn0172-6390
dc.identifier.issue124en_US
dc.identifier.pmid23165188
dc.identifier.scopus2-s2.0-84879574359
dc.identifier.scopusqualityN/A
dc.identifier.startpage768en_US
dc.identifier.urihttps://doi.org/10.5754/hge11666
dc.identifier.urihttps://hdl.handle.net/11468/20304
dc.identifier.volume60en_US
dc.identifier.wosWOS:000320740700027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherH G E Update Medical Publishing S Aen_US
dc.relation.ispartofHepato-Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastrointestinal Stromal Tumorsen_US
dc.subjectPrognosisen_US
dc.subjectTurkeyen_US
dc.titlePrognostic Factors in Gastrointestinal Stromal Tumors: Multicenter Experience of 333 Cases from Turkeyen_US
dc.titlePrognostic Factors in Gastrointestinal Stromal Tumors: Multicenter Experience of 333 Cases from Turkey
dc.typeArticleen_US

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