Pazopanib for metastatic soft-tissue sarcoma: A multicenter retrospective study

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dc.contributor.authorKoca, Sinan
dc.contributor.authorBesiroglu, Mehmet
dc.contributor.authorOzcelik, Melike
dc.contributor.authorKaraca, Mustafa
dc.contributor.authorBilici, Mehmet
dc.contributor.authorHacioglu, Bekir
dc.contributor.authorDogu, Gamze G.
dc.date.accessioned2024-04-24T17:14:40Z
dc.date.available2024-04-24T17:14:40Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose Soft tissue sarcomas are associated with a poor prognosis and low chemotherapeutic efficiency. Pazopanib is an orally available multi-tyrosine kinase inhibitor that was explored in patients with non-adipocytic advanced soft tissue sarcomas. The aim of this retrospective study was to evaluate the real life data of single-agent pazopanib efficacy and safety for soft tissue sarcomas in the Turkish population. Materials and methods We evaluated a total of 103 patients (41 males, 62 females) who received pazopanib for advanced non-adipocytic soft tissue sarcomas diagnosis in eight centers of Turkey, retrospectively. The pazopanib dose was 800 mg once daily. Progression-free survival, overall survival, and adverse events were analyzed. Results The median age was 50 years (range, 38-58). Majority of the patients had leimyosarcoma (41%). Median progression-free survival was 4.3 months, and the median overall survival was 10.1 months. The main common toxicities were fatigue, anorexia, weight loss, nausea, hypertension, and grade >= 3 toxicities were fatigue, anorexia, weight loss, and liver disorder. Conclusion Pazopanib is an efficient and tolerable agent and is well tolerated in good performance status patients with relapsed, advanced non-adipocytic soft tissue sarcomas.en_US
dc.identifier.doi10.1177/1078155220924075
dc.identifier.endpage546en_US
dc.identifier.issn1078-1552
dc.identifier.issn1477-092X
dc.identifier.issue3en_US
dc.identifier.pmid32419618
dc.identifier.scopus2-s2.0-85084830817
dc.identifier.scopusqualityQ3
dc.identifier.startpage541en_US
dc.identifier.urihttps://doi.org/10.1177/1078155220924075
dc.identifier.urihttps://hdl.handle.net/11468/18130
dc.identifier.volume27en_US
dc.identifier.wosWOS:000534051900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Oncology Pharmacy Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPazopaniben_US
dc.subjectSoft Tissue Sarcomaen_US
dc.subjectTargeted Therapyen_US
dc.titlePazopanib for metastatic soft-tissue sarcoma: A multicenter retrospective studyen_US
dc.titlePazopanib for metastatic soft-tissue sarcoma: A multicenter retrospective study
dc.typeArticleen_US

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