Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

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dc.contributor.authorUzar, Ertugrul
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorToprak, Guelten
dc.contributor.authorAcar, Abdullah
dc.contributor.authorYucel, Yavuz
dc.contributor.authorCalisir, Tugba
dc.contributor.authorCevik, Mehmet Ugur
dc.date.accessioned2024-04-24T16:02:03Z
dc.date.available2024-04-24T16:02:03Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractAsymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 +/- A 7.7, 31.0 +/- A 6.2 mu mol/L, respectively, p = 0.005) and ADMA (0.409 +/- A 0.028, 0.381 +/- A 0.044 mu mol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.en_US
dc.identifier.doi10.1007/s10194-011-0323-7
dc.identifier.endpage243en_US
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.issue2en_US
dc.identifier.pmid21359872
dc.identifier.scopus2-s2.0-85027922830
dc.identifier.scopusqualityQ1
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.1007/s10194-011-0323-7
dc.identifier.urihttps://hdl.handle.net/11468/14600
dc.identifier.volume12en_US
dc.identifier.wosWOS:000289290400017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal of Headache and Pain
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectNitric Oxideen_US
dc.subjectOxidative Stressen_US
dc.subjectEndothelial Dysfunctionen_US
dc.titleIncreased asymmetric dimethylarginine and nitric oxide levels in patients with migraineen_US
dc.titleIncreased asymmetric dimethylarginine and nitric oxide levels in patients with migraine
dc.typeArticleen_US

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