Glucose-6-phosphate dehydrogenase deficiency and kernicterus of south-east Anatolia

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dc.contributor.authorKatar, Selahattin
dc.date.accessioned2024-04-24T17:08:23Z
dc.date.available2024-04-24T17:08:23Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the rate of kernicterus, and physical and laboratory examination findings in hyperbilirubinemic infants with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Materials and Methods: This study was carried out in the Dicle University Hospital Neonatal Intensive Care Unit between June 2005 and June 2006. Out of 56 male neonates who needed an exchange transfusion due to hyperbilirubinemia, 10 with G-6-PD deficiency were included in the study. Maternal age.. gestational age, route of delivery, birth weight, age at the time of admission, and treatment and outcome were recorded. Laboratory investigations included determination of direct and indirect serum bilirubin concentrations, blood group typing, direct Coomb test, complete blood count, blood smear, thyroid-stimulating hormone, T4, C-reactive protein, urine analysis, and G-6-PD level. Results: Out of 56 male neonates requiring exchange transfusion, 10 had G-6-PD deficiency (18%). In G-6-PD deficient neonates, other factors known to cause hyperbilirubinemia were excluded. The mean gestational age and the mean maternal age was 38.2 +/- 1.0 weeks and 31.3 +/- 5.9 years, respectively. The mean bilirubin level was 42.1 +/- 13.7 mg/dL. Four patients required a second exchange transfusions, and only I transfusion was sufficient for the remaining patients. Five patients (55%) developed kernicterus. Conclusions: Early detection of G-6-PD deficiency in the affected newborns may be important for reducing the risk of severe hyperbilirubinemia, kernicterus, and the need for exchange transfusion.en_US
dc.identifier.doi10.1097/MPH.0b013e31805180dc
dc.identifier.endpage286en_US
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue5en_US
dc.identifier.pmid17483701
dc.identifier.scopus2-s2.0-34248230830
dc.identifier.scopusqualityQ3
dc.identifier.startpage284en_US
dc.identifier.urihttps://doi.org/10.1097/MPH.0b013e31805180dc
dc.identifier.urihttps://hdl.handle.net/11468/17324
dc.identifier.volume29en_US
dc.identifier.wosWOS:000246463900003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Pediatric Hematology Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKernicterusen_US
dc.subjectGlucose-6-Phosphate Dehydrogenase Deficiencyen_US
dc.titleGlucose-6-phosphate dehydrogenase deficiency and kernicterus of south-east Anatoliaen_US
dc.titleGlucose-6-phosphate dehydrogenase deficiency and kernicterus of south-east Anatolia
dc.typeArticleen_US

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