Micronized purified flavonoid fraction may prevent formation of intraperitoneal adhesions in rats

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dc.contributor.authorYilmaz, HG
dc.contributor.authorTacyildiz, IH
dc.contributor.authorKeles, C
dc.contributor.authorGedik, E
dc.contributor.authorKilinc, N
dc.date.accessioned2024-04-24T16:11:31Z
dc.date.available2024-04-24T16:11:31Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To evaluate the efficacy of an anti-inflammatory and capillary regulator drug, micronized purified flavonoid fraction (MPFF), in the prevention of postoperative formation of adhesions. Design: A double-blind, controlled study evaluated the efficacy of MPFF in reducing postoperative adhesion formation in a rat model. Setting: Animal care facility of an academic research setting. Animal(s): Thirty Sprague-Dawley female rats randomly divided into three groups. Intervention(s): Starting on day of surgery, group 2 rats received oral MPFF (100 mg/kg per day for 7 days). Group 3 rats were intraperitoneally injected with 5 mL of saline (containing 200 mg/kg per day of MPFF for 3 days). Control rats received no medication. A standardized surgical trauma was applied in all animals. Three weeks after surgery, the rats were killed, and the adhesions were scored according to macroscopic and microscopic scales. Main Outcome Measure(s): Postoperative adhesions. Result(s): Both oral and intraperitoneal administration of MPFF reduced the scores of adhesions according to macroscopic and microscopic scales. There was no difference between the routes of administration. Conclusion(s): A statistically significant reduction in postoperative formation of adhesions was observed after oral and intraperitoneal administration of MPFF in our experimental animal model. However, further studies are required to reveal its mechanism of action.en_US
dc.identifier.doi10.1016/j.fertnstert.2005.03.076
dc.identifier.endpage1088en_US
dc.identifier.issn0015-0282
dc.identifier.pmid16209997en_US
dc.identifier.scopus2-s2.0-25844507180en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1083en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2005.03.076
dc.identifier.urihttps://hdl.handle.net/11468/15417
dc.identifier.volume84en_US
dc.identifier.wosWOS:000232604700004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntraabdominal Adhesionen_US
dc.subjectMicronized Purified Flavonoid Fractionen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectCapillary Regulatoren_US
dc.titleMicronized purified flavonoid fraction may prevent formation of intraperitoneal adhesions in ratsen_US
dc.typeArticleen_US

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