Hodgkin's disease and association with Epstein-Barr virus in children in Southeast Turkey

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dc.contributor.authorYilmaz, F
dc.contributor.authorUzunlar, AK
dc.contributor.authorSogutcu, N
dc.contributor.authorOzaydin, M
dc.date.accessioned2024-04-24T17:37:30Z
dc.date.available2024-04-24T17:37:30Z
dc.date.issued2005
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: There are relatively few reports on histologic and immunophenotypic features of Hodgkin's disease (HD) in children in Turkey. The aim of the present study is to characterize the clinicopathologic, immunophenotypic features and Ebstein-Barr virus (EBV) status of HD in children in our region. Methods: Fifty-two cases coded as HD in the Department of Pathology, Medical Faculty, Dicle University, Turkey, from 1990 to 2002 were retrieved. We analyzed clinicopathologic data, immunophenotype, and EBV status of all patients. Results: In most cases, the cervical lymph nodes were involved. The 52 cases (35 boys, 17 girls; male to female ratio was 2.1) were categorized as mixed cellularity (MC) in 23 (44.2%), lymphocyte predominance (LP) in 16 (30.8%), nodular sclerosis (NS) in 10 (19.2%), and lymphocyte depletion (LD) in 3 (5.8%). Of 33 cases, including MC and NS, Hodgkin's Reed-Sternberg cells and variants were positive for CD15 in 27 cases (81.8%) and positive for CD30 in 30 cases (90.9%). All the cases of LP demonstrated the characteristic phenotype of this variant (CD45RB+, CD20+, CD15-, CD30-). Epithelial membrane antigen stained the lymphocytic/histiocytic cells in 3 cases (18.7%) of 16. Ebstein-Barr virus-LMP1 were positive in 31 cases (61.5%) of a total of 52 cases and the most were MC (91.3%). Conclusion: In conclusion, mixed cellularity HD is the most common histologic subtype. This result differed from that reported in developed countries. We found a striking association with expression of EBV-latent membrane protein 1 in malignant cells in childhood HD.en_US
dc.identifier.endpage575en_US
dc.identifier.issn0379-5284
dc.identifier.issue4en_US
dc.identifier.pmid15900362
dc.identifier.scopus2-s2.0-19044372590
dc.identifier.scopusqualityQ2
dc.identifier.startpage571en_US
dc.identifier.urihttps://hdl.handle.net/11468/20965
dc.identifier.volume26en_US
dc.identifier.wosWOS:000229422200011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleHodgkin's disease and association with Epstein-Barr virus in children in Southeast Turkeyen_US
dc.titleHodgkin's disease and association with Epstein-Barr virus in children in Southeast Turkey
dc.typeArticleen_US

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