Effect of lymphedema on the recovery of fractures

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dc.contributor.authorArslan, Hueseyin
dc.contributor.authorUludag, Abuzer
dc.contributor.authorKapukaya, Ahmet
dc.contributor.authorGezici, Ayten
dc.contributor.authorBekler, H. Ibrahim
dc.contributor.authorKetani, Aydin
dc.date.accessioned2024-04-24T16:01:58Z
dc.date.available2024-04-24T16:01:58Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. Lymphedema delays the healing of any wound by negatively affecting its inflammatory period. Whether it affects bone healing in a similar negative manner is unknown. Therefore, we experimentally investigated the effect of lymphedema on fracture recovery. Methods. We used thirty 200- to 250-g Sprague-Dawley rats for the experiment. The rats were randomly divided into two groups of 15 rats each for the experimental lymphedema and control groups. Lymphedema development was confirmed by measuring the circumference and diameter of the extremities together with lymphoscintigraphy. Twenty days after the development of lymphedema, a fracture model was created in both groups in the right tibia with mid-diaphyseal osteotomy and fixing with an intramedullary Kirschner wire. After 6 weeks, all rats were sacrificed and the callus tissue that formed along the osteotomy was compared between groups with respect to radiographic, histological, and biomechanical characteristics. Results. The three-point bending test yielded an average stiffness value of 1227 N/mm (n = 6) in the control group and 284 N/mm (n = 7) in the experimental lymphedema group (P < 0.05). At the end of week 6, radiographic evaluation showed that solid knitting was obtained in the control group, whereas in the lymphedema group delayed or no knitting was observed. In the control group, histological investigation revealed normal callus morphology. Trabecular bone was normal and osteoblast and osteoclast activity was clearly evident. The bone was stained homogeneously with hematoxylin and eosin, and ossification was within normal limits. In the lymphedema group, however, the histological appearance was mostly that of scar tissue. In addition, osteoblast and osteoclast activity was much less visible or absent. Conclusions. Lymphedema negatively affected bone healing in rats. However, the mechanism of this negative effect and its occurrence in humans are still unknown. Further experimental and clinical studies are needed to support and extend our findings.en_US
dc.identifier.doi10.1007/s00776-007-1175-5
dc.identifier.endpage584en_US
dc.identifier.issn0949-2658
dc.identifier.issn1436-2023
dc.identifier.issue6en_US
dc.identifier.pmid18040641
dc.identifier.scopus2-s2.0-36549023135
dc.identifier.scopusqualityQ2
dc.identifier.startpage578en_US
dc.identifier.urihttps://doi.org/10.1007/s00776-007-1175-5
dc.identifier.urihttps://hdl.handle.net/11468/14543
dc.identifier.volume12en_US
dc.identifier.wosWOS:000251225600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Orthopaedic Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffect of lymphedema on the recovery of fracturesen_US
dc.titleEffect of lymphedema on the recovery of fractures
dc.typeArticleen_US

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