Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

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dc.contributor.authorOguz, Abdullah
dc.contributor.authorUslukaya, Omer
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorTurkoglu, Ahmet
dc.contributor.authorKapan, Murat
dc.contributor.authorBozdag, Zubeyir
dc.date.accessioned2024-04-24T17:33:08Z
dc.date.available2024-04-24T17:33:08Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, we aimed to compare the effects of dexpanthenol and N-acetylcysteine on wound healing. The wound healing process is a multifaceted sequence of activities associated with tissue restoration process. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. A total of 30 rats were divided into 3 equal groups. A linear 2-cm incision was made in the rats' skin. No treatment was administered in the first (control) group. Dexpanthenol cream was administered to the rats in the second group and 3% N-acetylcysteine cream was administered to the rats in the third group. The wound areas of all of the rats were measured on certain days. On the 21st day, all wounds were excised and histologically evaluated. The epithelialization and granulation rates between the groups were revealed to be similar in microscopic evaluations. Although the fibrosis was remarkable in the control group as compared with the other groups, it was similar in N-acetylcysteine and dexpanthenol groups. Angiogenesis rate was remarkable in the N-acetylcysteine group compared with the others. In multiple-comparison analysis, Dexpanthenol and N-acetylcysteine groups had similar results in terms of wound healing rates (P < 0.05), which were both higher than in the control group (P > 0.05). The efficacy of N-acetylcysteine in wound healing is comparable to dexpanthenol, and both substances can be used to improve wound healing.en_US
dc.identifier.doi10.9738/INTSURG-D-14-00227.1
dc.identifier.endpage661en_US
dc.identifier.issn0020-8868
dc.identifier.issue4en_US
dc.identifier.pmid25583306
dc.identifier.scopus2-s2.0-84975073329
dc.identifier.scopusqualityQ4
dc.identifier.startpage656en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-14-00227.1
dc.identifier.urihttps://hdl.handle.net/11468/20466
dc.identifier.volume100en_US
dc.identifier.wosWOS:000353028900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectDexpanthenolen_US
dc.subjectWound Healingen_US
dc.titleTopical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Studyen_US
dc.titleTopical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study
dc.typeArticleen_US

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