Influence of Indole-3-butyric acid on antioxidant defense systems in various tissues of rats at subacute and subchronic exposure

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dc.contributor.authorTopalca, Nuray
dc.contributor.authorYegin, Esref
dc.contributor.authorCelik, Ismail
dc.date.accessioned2024-04-24T16:11:30Z
dc.date.available2024-04-24T16:11:30Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study was carried out to investigate the effects of Indole-3-butyric acid (IBA), a plant growth regulator (PGR), on antioxidant defense systems (ADS) such as reduced glutathione (GSH) level and Glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) superoxide dismutase (SOD) enzymes activity in various tissues of rats exposed to 25 and 50 ppm dosages of IBA for 20 and 45 days. Results showed that the administrations of IBA fluctuated GSH levels in some tissues of rats treated with both dosages and periods. With regard to the ADS enzymes, SOD and GST activities increased significantly in the most of the tissues in rats treated with both dosages and periods of IBA. Also, GSH-Px activity fluctuated after subacute and subchronic exposure with both dosages in some of the tissues in rats compared to that the control rats. The observations presented led us to conclude that the administrations of IBA at subacute and subchronic affected the ADS system in various tissues of rats. This may reflect the potential role of these parameters as useful biomarkers for toxicity of IBA. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipUniversity Grant Commission The University of Yuzuncu Yil [2007-FBE-YL77]en_US
dc.description.sponsorshipThe authors are grateful to the University Grant Commission (The University of Yuzuncu Yil, No. 2007-FBE-YL77) for providing financial assistance during the tenure of Research Associate ship.en_US
dc.identifier.doi10.1016/j.fct.2009.06.037
dc.identifier.endpage2444en_US
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue10en_US
dc.identifier.pmid19577605
dc.identifier.scopus2-s2.0-69549123882
dc.identifier.scopusqualityQ1
dc.identifier.startpage2441en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2009.06.037
dc.identifier.urihttps://hdl.handle.net/11468/15412
dc.identifier.volume47en_US
dc.identifier.wosWOS:000270527000008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndole-3-Butyric Aciden_US
dc.subjectAntioxidant Defense Systemsen_US
dc.subjectRaten_US
dc.titleInfluence of Indole-3-butyric acid on antioxidant defense systems in various tissues of rats at subacute and subchronic exposureen_US
dc.titleInfluence of Indole-3-butyric acid on antioxidant defense systems in various tissues of rats at subacute and subchronic exposure
dc.typeArticleen_US

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