LC-HRMS profiling of phytochemicals with assessment of antioxidant, anticholinesterase, and antimicrobial potentials of astragalus brachystachys DC

Basit Öğe Kaydı
dc.authorid0000-0002-6913-1952en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorErsoy, Ezgi
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorKaplan, Alevcan
dc.contributor.authorMataracı, Emel Kara
dc.contributor.authorKayıran, Serpil Demirci
dc.contributor.authorEroğlu, Esra Özkan
dc.date.accessioned2025-04-24T06:10:24Z
dc.date.available2025-04-24T06:10:24Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractAstragalus species are ubiquitous in the pharmacopeia of numerous countries, signifying their widespread medicinal applications. Türkiye is esteemed as one of the principal epicenters of diversity for this genus with 483 taxa, and many of these plants have been traditionally utilized for diseases including coughing, diabetes, cardiovascular disorders, and aches. Although there is a considerable body of chemical and biological research available on several Astragalus species, studies focusing on Astragalus brachystachys DC are exceedingly rare. In this context, This study provides the first comprehensive report on this medicinal plant the chemical constituents and biological activities of an important medicinal plant, Astragalus brachystachys DC. The aerial part samples were collected from Adana, Türkiye, and an ethanol extract was prepared with these parts. The secondary metabolites of the extract were determined by an LC-HRMS analysis. The LC-HRMS analysis showed the presence of 39 different constituents, hyperoside (303.419±10.50 μg/g extract), p-coumaric acid (256.975±8.51 μg/g extract), and rutin (72.684±2.23 μg/g extract) were determined as major compounds in the aerial parts ethanol extract. Attributed to its high total phenolic (58.53±1.30 μg PEs/mg extract) and total flavonoid content (29.98±0.83 μg QEs/mg extract), the extract demonstrated strong antioxidant activity according to three different assays namely DPPH free (IC50: 33.08±0.61 μg/mL), and ABTS cation radical scavenging (IC50: 15.39±0.72 μg/mL) and CUPRAC activity (A0.5: 36.25±0.28 μg/mL) methods. In vitro assays showed that cholinesterase inhibitory activity results were found to be exceptional with 85.95±0.52 % inhibition on acetylcholinesterase and 66.32±1.33 % inhibition on butyrylcholinesterase at 200 μg/mL. Regarding antimicrobial properties, Astragalus brachystachys DC extract was found to be effective against Enterococcus faecalis with a MIC value of 39.06 μg/mL.en_US
dc.identifier.citationErsoy, E., Boğa, M., Kaplan, A., Mataracı, E. K., Eroğlu, E. Ö. ve Kayıran, S. D. (2024). LC-HRMS profiling of phytochemicals with assessment of antioxidant, anticholinesterase, and antimicrobial potentials of astragalus brachystachys DC. Chemistry and Biodiversity, 1-10.en_US
dc.identifier.endpage10en_US
dc.identifier.issn1612-1872
dc.identifier.pmid39400994en_US
dc.identifier.scopus2-s2.0-85209115534en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.202401853
dc.identifier.urihttps://hdl.handle.net/11468/32222
dc.identifier.wosWOS:001356839900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistry and Biodiversityen_US
dc.relation.isversionof10.1002/cbdv.202401853en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectAstragalus brachystachysen_US
dc.subjectCholinesterase inhibitionen_US
dc.subjectLC-HRMSen_US
dc.titleLC-HRMS profiling of phytochemicals with assessment of antioxidant, anticholinesterase, and antimicrobial potentials of astragalus brachystachys DCen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
LC-HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus Brachystachys DC.pdf
Boyut:
1.41 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Eczacılık Meslek Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu