Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index

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dc.contributor.authorKarabacak, Ercan
dc.contributor.authorAydin, Ersin
dc.contributor.authorKutlu, Au
dc.contributor.authorOzcan, Omer
dc.contributor.authorMuftuoglu, Tuba
dc.contributor.authorGunes, Ali
dc.contributor.authorDogan, Bilal
dc.date.accessioned2024-04-24T17:24:51Z
dc.date.available2024-04-24T17:24:51Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: Atopic dermatitis (AD) is a chronic, pruritic inflammatory disease, characterized by a relapsing-remitting course. The pathogenesis of atopic dermatitis is not completely understood, although the disorder appears to result from the complex interaction between immune abnormalities, genetic and environmental factors. Trace elements are essential for normal functioning of the immune system. Aim: To determine zinc levels in serum and erythrocytes of patients with AD using an atomic absorption spectro-metric technique and to investigate the relationship between those levels and disease activity. Material and methods: Sixty-seven patients and 49 controls were enrolled into the study. The disease severity of AD patients was determined according to the Scoring Atopic Dermatitis (SCORAD) index. We measured zinc levels in serum and erythrocytes by the atomic absorption spectrophotometric technique. Results: Erythrocyte zinc levels were significantly lower in AD patients than in the control group (p < 0.001), whereas serum zinc levels did not differ between the groups (p = 0.148). In the AD patient group there was a negative correlation between the SCORAD score and erythrocyte zinc levels (r = 0.791; p < 0.001). Conclusions: The negative relationship between disease severity and erythrocyte zinc levels might suggest an immunopathological link between AD progression and intracellular zinc metabolism.en_US
dc.identifier.doi10.5114/ada.2016.62841
dc.identifier.endpage352en_US
dc.identifier.issn1642-395X
dc.identifier.issue5en_US
dc.identifier.pmid27881941
dc.identifier.scopus2-s2.0-84992365714
dc.identifier.scopusqualityQ2
dc.identifier.startpage349en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2016.62841
dc.identifier.urihttps://hdl.handle.net/11468/19857
dc.identifier.volume33en_US
dc.identifier.wosWOS:000386539100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtopic Dermatitisen_US
dc.subjectZincen_US
dc.subjectErythrocyteen_US
dc.subjectScoring Atopic Dermatitisen_US
dc.titleErythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD indexen_US
dc.titleErythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index
dc.typeArticleen_US

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