Effects of potentilla fulgens as prophylactic agent in intestinal ischemia reperfusion injury

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dc.authorid0000-0002-3894-4766en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorTunç, Nurettin
dc.contributor.authorTaş, Mahmut
dc.contributor.authorGörük, Mücahit
dc.contributor.authorKirman, Günsel
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-03T12:37:46Z
dc.date.available2024-04-03T12:37:46Z
dc.date.issued2015en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe purpose of this study, ischemia reperfusion injury in rats, Potentilla fulgens is to investigate the protective effects. Wistar albino rats (n= 30) weighing 180-220 g were used in the experiment. Group 1 animals underwent sham laparotomy without ischemiareperfusion injury. Group 2 animals underwent laparotomy and occlusion of superior mesenteric arteries for 30 min followed by 20 min of reperfusion without pretreatment. The Potentilla fulgens group received 400 mg/kg/day Potentilla fulgens intraperitoneally 5 days before Ischemia-reperfusion injury. There was a significant difference between the group with ischemia-reperfusion group Potentilla fulgens (p<0.0001). In statistical analysis of the MDA level, data were obtained after a respective measurement in all groups. Potentilla fulgens group with ischemia-reperfusion group was a significant decrease in MDA (p<0.001). In the period after ischemia-reperfusion, marked PCNA immunoreactivities were observed in the nuclei of crypt and villus cell. In ischemia reperfusion group, the number of PCNA immunoreactivity is quite advanced and they extended throughout the middle part of the intestine folds. The number of TUNEL-positive nuclei were also developed. In ischemia-reperfusion plus P. fulgens group, the intestinal epithelium with only a few PCNA immunoreactive nuclei. TUNEL positive nuclei were noted in the gut lumen and mucosal close differentiated goblet cells. We showed that Potentilla fulgens extract significantly prevented mucosal lesions caused by intestinal ıschemia-reperfusion.en_US
dc.identifier.citationTunç, N., Taş, M., Görük, M., Kirman, G. ve Deveci, E. (2015). Effects of potentilla fulgens as prophylactic agent in intestinal ischemia reperfusion injury. International Journal of Morphology, 33(4), 1313-1318.en_US
dc.identifier.doi10.4067/S0717-95022015000400020en_US
dc.identifier.endpage1318en_US
dc.identifier.issn0717-9367
dc.identifier.issue4en_US
dc.identifier.startpage1313en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400020&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/13813
dc.identifier.volume33en_US
dc.identifier.wosWOS:000371997400019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKirman, Günsel
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal ischemiaen_US
dc.subjectProliferating Cell Nuclear Antigen (PCNA)en_US
dc.subjectRaten_US
dc.subjectTunnel methoden_US
dc.titleEffects of potentilla fulgens as prophylactic agent in intestinal ischemia reperfusion injuryen_US
dc.title.alternativeEfectos de potentilla fulgens como agente profiláctico en la lesión por isquemia-reperfusión intestinalen_US
dc.typeArticleen_US

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