Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats

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dc.contributor.authorHekimoglu, Askm Tas
dc.contributor.authorToprak, Gulten
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorOzekinci, Selver
dc.contributor.authorKelle, Ilker
dc.date.accessioned2024-04-24T17:24:21Z
dc.date.available2024-04-24T17:24:21Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractRenal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated group; (2) Sham operated+OT group (3) Renal IR group; (4) Renal IR+OT group. OT (500 mu g/kg) was administered subcutaneously 12 and 24 hours before and immediately after ischemia. At the end of experimental procedure, the rats were sacrificed, and liver specimens were taken for histological assessment or determination of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). The results showed that renal IR injury constituted a notable elevation in MDA, TOS, Oxidative stress index (OSI) and significantly decreased TAS, PON-1 actvity and NO in liver tissue (p<0.05). Additionally renal IR provoked significant augmentation in hepatic microscopic damage scores. However, alterations in these biochemical and histopathological indices due to IR injury were attenuated by OT treatment (p<0.05). These findings show that OT ameliorates remote liver damage triggered by renal ischemia-reperfusion and this preservation involves suppression of inflammation and regulation of oxidant-antioxidant status.en_US
dc.identifier.doi10.4196/kjpp.2013.17.2.169
dc.identifier.endpage173en_US
dc.identifier.issn1226-4512
dc.identifier.issn2093-3827
dc.identifier.issue2en_US
dc.identifier.pmid23626480
dc.identifier.scopus2-s2.0-84877974798
dc.identifier.scopusqualityQ3
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.4196/kjpp.2013.17.2.169
dc.identifier.urihttps://hdl.handle.net/11468/19630
dc.identifier.volume17en_US
dc.identifier.wosWOS:000334564600009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Journal Of Physiology & Pharmacologyen_US
dc.relation.ispartofKorean Journal of Physiology & Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectOxytocinen_US
dc.subjectRemote Liver Injuryen_US
dc.titleOxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Ratsen_US
dc.titleOxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats
dc.typeArticleen_US

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