Antidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic rats

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dc.contributor.authorDogan, Abdulahad
dc.contributor.authorCelik, Ismail
dc.contributor.authorKaya, Mehmet Salih
dc.date.accessioned2024-04-24T16:15:05Z
dc.date.available2024-04-24T16:15:05Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractEthnopharmacological relevance: Acorn obtained from the Quercus brantii Lindl. (QB) tree has been used in Turkish folk medicine. Some studies have reported as an antioxidant, antimicrobial, anti-inflammatory, gastroprotective, antitumoural of QB properties previously, however, its effect on the management of type diabetic 2 and oxidative stress complications is still unexplored. The aims of our study were the evaluation of the protective effect and antioxidant role of acorn lyophilized seed plant extract against STZ-induced diabetic complications as oxidative stress, hepatotoxicity and nephropathy, lipidemia and serum biomarkers of diabetes (SBD). Materials and methods: In-vivo studies were performed on STZ-induced diabetic rats Experiment was designed as I [Normal Control (NC)], II [Diabetes mellitus (DM)], III [DM+Acarbose (20 mg/kg b.w) (DM+AC-20)], IV [DM+ QB (100 mg/kg b.w) (DM+QB-100)], V [DM+QB (250 mg/kg b.w) (DM+ QB-250)] and VI [DM+QB (500 mg/kg b.w) (DM+QB-500)] groups. Results: This study showed that the biochemical analysis showed a considerable increase in the HRDB, DB, LP, MDA and fluctuated ADSC in the II group as compared to that of control group whereas, AC and the plant lyophilized seed plant extract supplementations diet restored the STZ-induced diabetic complications towards the control. alpha-glycosidase activity in DM group showed statistically significant increase with respect to control group in small intestine. Moreover, in accordance with the effects of seed extract; in diabetic rat groups to whom acorn seed extract and acarbose were given, the levels of almost all the concerned parameters were reached to the ones measured at control group. As a result, it was concluded that acorn seed extract had certain healing effects on many complications caused by diabetes. (c) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipUniversity of Yuzuncu Yil Grant Commission [YYU-BAP-2013-FBE-D064]en_US
dc.description.sponsorshipNone of the authors has a commercial interest, financial interest, and/or other relationship with manufacturers of pharmaceuticals, laboratory supplies, and/or medical devices or with commercial providers of medically related services. The authors are grateful to the University of Yuzuncu Yil Grant Commission for providing financial assistance during the tenure of research numbered with YYU-BAP-2013-FBE-D064. Ismail Celik was the main moderator of the study. Abdulahad Dogan and Mehmet Salih Kaya performed the biochemical investigation and treatment in this study.en_US
dc.identifier.doi10.1016/j.jep.2015.10.034
dc.identifier.endpage251en_US
dc.identifier.issn0378-8741
dc.identifier.issn1872-7573
dc.identifier.pmid26505295
dc.identifier.scopus2-s2.0-84946716357
dc.identifier.scopusqualityQ1
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1016/j.jep.2015.10.034
dc.identifier.urihttps://hdl.handle.net/11468/15637
dc.identifier.volume176en_US
dc.identifier.wosWOS:000367106600019
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcornen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectOxidative Stressen_US
dc.subjectSerum Biomarkersen_US
dc.subjectAntioxidant Defense Systemen_US
dc.subjectMalondialdehydeen_US
dc.subjectRatsen_US
dc.titleAntidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic ratsen_US
dc.titleAntidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic rats
dc.typeArticleen_US

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