The efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis

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dc.contributor.authorAyaz, Celal
dc.contributor.authorCelen, Mustafa K.
dc.contributor.authorGeyik, Mehmet F.
dc.contributor.authorUlug, Mehmet
dc.date.accessioned2024-04-24T17:39:56Z
dc.date.available2024-04-24T17:39:56Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To evaluate the efficacy of dexamethasone added to the treatment of adult patients with bacterial meningitis in our region. Methods: One hundred and forty-four patients were randomized prospectively and evaluated to determine the efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis at Dicle University Hospital, Diyarbakir, Turkey between January 2000 and December 2004. While the first group received ceftriaxone 4 gr/day plus dexamethasone, the second group received ceftriaxone 4 gr/day only. Dexamethasone was given 10-15 minutes before the first 8 mg dose of antibiotic treatment. It was continued at 16 mg/day for 3 days. Results: The study included 144 patients with the diagnosis of acute bacterial meningitis. Cerebrospinal fluid (CSF) was analyzed at the time of admission, after 24-48 hours (Table 1), and at the end of treatment. Accordingly, CSF leukocyte level was found to be 1710 2140/mm(3) in group 1 receiving dexamethasone treatment compared to 1950 +/- 2244/mm(3) in group 2 (p=0.001). The consciousness in the group receiving dexamethasone improved significantly more rapidly than the control group (p=0.001). While mortality was 9.7% in the patient group receiving dexamethasone it was 16.7% in the control group, however, it was not significant (p=0.093). Conclusion: The use of dexamethasone in adult patients is still under debate, and the administration of dexamethasone 10-15 minutes before antibiotherapy to unconscious patients in a poor state of health, is effective in the clinical improvement of the patient.en_US
dc.identifier.endpage150en_US
dc.identifier.issn1319-6138
dc.identifier.issue2en_US
dc.identifier.pmid21063309
dc.identifier.scopus2-s2.0-45749147521
dc.identifier.scopusqualityQ3
dc.identifier.startpage146en_US
dc.identifier.urihttps://hdl.handle.net/11468/21443
dc.identifier.volume13en_US
dc.identifier.wosWOS:000255972800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRiyadh Armed Forces Hospitalen_US
dc.relation.ispartofNeurosciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe efficacy of dexamethasone treatment in adult patients with acute bacterial meningitisen_US
dc.titleThe efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis
dc.typeArticleen_US

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