Immunohistochemical analysis of vimentin and Zonula Occludens-1 in placentas of patients with PPROM

Basit Öğe Kaydı
dc.authorid0000-0002-6384-9146en_US
dc.authorid0000-0002-9714-4670en_US
dc.authorid0000-0001-7317-5467en_US
dc.authorid0000-0002-2353-1184en_US
dc.authorid0000-0001-7634-3008en_US
dc.contributor.authorZaman, Fuat
dc.contributor.authorAşır, Fırat
dc.contributor.authorErmiş, Işılay Sezen
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorDeveci, Engin
dc.contributor.authorOğlak, Süleyman Cemil
dc.date.accessioned2024-04-05T05:58:07Z
dc.date.available2024-04-05T05:58:07Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: We aimed to investigate the immunohistochemical staining of vimentin and zonula occludens-1 (ZO-1) expression in the placentas of pregnant women with preterm premature rupture of membranes (PPROM). Methods: Placentas of 25 healthy and 25 women with PPROM were fixed in 10% formaldehyde solution and further processed for paraffin wax tissue embedding. Demographic properties of patients were recorded. Placentas were histologically stained with hematoxylin-eosin and vimentin and ZO-1 expression immunostaining. Results: Vimentin expression was high in the decidual cells, fibroblasts, and connective tissue fibers in control group. Compared to control group, vimentin expression was decreased in the placental structures of PPROM group, where fetal membranes were degenerated and histologically irregular. Similar to vimentin expression, ZO-1 expression was also high in placental components of control group such as chorioamniotic membrane and amniotic epithelium. The PPROM group showed lower expression of ZO-1 expression in placental structures than in that of control. ZO-1 expression was significantly lowered in regions where fetal membrane integrity was weakened and lost. Conclusions: We suggest that ZO-1 and vimentin expression may show alteration in etiology premature rupture of membrane.en_US
dc.identifier.citationZaman, F., Aşır, F., Ermiş, I. S., Tuncer, M. C., Deveci, E. ve Oğlak, S. C. (2024). Immunohistochemical analysis of vimentin and Zonula Occludens-1 in placentas of patients with PPROM. Clinical and Experimental Obstetrics and Gynecology, 51(1), 1-6.en_US
dc.identifier.doi10.31083/j.ceog5101018
dc.identifier.endpage6en_US
dc.identifier.issn0390-6663
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85182933136
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.imrpress.com/journal/CEOG/51/1/10.31083/j.ceog5101018
dc.identifier.urihttps://hdl.handle.net/11468/13848
dc.identifier.volume51en_US
dc.identifier.wosWOS:001155736600019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAşır, Fırat
dc.institutionauthorTuncer, Mehmet Cudi
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherIMR Press Limiteden_US
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPROMen_US
dc.subjectAmniotic membraneen_US
dc.subjectJunctionen_US
dc.subjectHistopathologyen_US
dc.titleImmunohistochemical analysis of vimentin and Zonula Occludens-1 in placentas of patients with PPROMen_US
dc.titleImmunohistochemical analysis of vimentin and Zonula Occludens-1 in placentas of patients with PPROM
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Immunohistochemical Analysis of Vimentin and Zonula Occludens-1 in Placentas of Patients with PPROM.pdf
Boyut:
1.13 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu