Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: A prospective, randomized, double-blind, placebo-controlled, multicenter study

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dc.contributor.authorCingi, Cemal
dc.contributor.authorSongu, Murat
dc.contributor.authorUral, Ahmet
dc.contributor.authorYildirim, Muzeyyen
dc.contributor.authorErdogmus, Nagehan
dc.contributor.authorBal, Cengiz
dc.date.accessioned2024-04-24T17:33:38Z
dc.date.available2024-04-24T17:33:38Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe conducted a prospective, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy of chlorhexidine gluconate/benzydamine HCl mouth spray for reducing pain and improving quality of life in patients with acute viral pharyngitis. Prior to treatment, patients rated the intensity of their pain on a visual analog scale and evaluated their quality of life on the 36-Item Short-Form Health Survey. Patients were then randomized to receive either paracetamol (acetaminophen) plus chlorhexidine/benzydamine or paracetamol plus placebo for 7 days. On days 3 and 7 of treatment, the participants again rated the intensity of their pain, and on day 7, they again rated their quality of life. A total of 164 patients were evaluable at study's end-80 in the chlorhexidine/benzydamine group and 84 in the control group. A comparison of self-evaluations revealed that the active treatment group reported less pain on both day 3 (p < 0.001) and day 7 (p = 0.002). Likewise, the chlorhexidine/benzydamine group reported a significantly better quality of life on day 7 (p < 0.001). Chlorhexidine/benzydamine was well tolerated, and no serious adverse events were observed.en_US
dc.identifier.endpage549en_US
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue11en_US
dc.identifier.pmid21086279
dc.identifier.scopus2-s2.0-78650101094
dc.identifier.scopusqualityQ2
dc.identifier.startpage546en_US
dc.identifier.urihttps://hdl.handle.net/11468/20784
dc.identifier.volume89en_US
dc.identifier.wosWOS:000284921400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: A prospective, randomized, double-blind, placebo-controlled, multicenter studyen_US
dc.titleEffects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: A prospective, randomized, double-blind, placebo-controlled, multicenter study
dc.typeArticleen_US

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