Comparison of OCT findings of schizophrenia patients using FGA, Clozapine, and SGA other than Clozapine
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Sao Paulo, Ins Psiquiatria
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The effect of antipsychotic (AP) drugs on optical coherence tomography (OCT) findings in schizophrenia has not yet been fully
elucidated. In this study, we aimed to investigate the effects of APs (the first generation antipsychotic group [FGAG], the second generation
antipsychotic group [SGAG], the clozapine group [CG]) on OCT findings in schizophrenia. Methods: The thickness of the retinal nerve
fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroidal thickness were measured using a spectral OCT
device. Results: No significant difference was found between FGAG, SGAG, CG (p > 0.05) while there was a significant difference between
the control group and the patients group in terms of RNFL, GCL, and IPL (p < 0.05). A significant difference between SGAG and CG, FGAG
(p < 0.05); between control group and FGAG (p < 0.05) were found in terms of choroidal thickness. Conclusion: These findings suggested
the deterioration of the metabolic parameters due to the SGA use. Thinner choroidal layer thickness in the CG compared to the SGAG and
control group was thought to be related to the patients using clozapine had a resistance to the treatment
Açıklama
WOS:000647554000001
Anahtar Kelimeler
Antipsychotics, Retinal ganglion cell, Choroid, Optical coherence tomography, Schizophrenia
Kaynak
Archives of Clinical Psychiatry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
47
Sayı
6
Künye
Orum, M.H., Bulut, M., Karadağ, A.S., Dumlupınar, E. ve Kalenderoğlu, A. (2020). Comparison of OCT findings of schizophrenia patients using FGA, Clozapine, and SGA other than Clozapine. Archives of Clinical Psychiatry, 47(6), 165-175.
