Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency

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dc.contributor.authorKarahan, Oguz
dc.contributor.authorYavuz, Celal
dc.contributor.authorKankilic, Nazim
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorTezcan, Orhan
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorMavitas, Binali
dc.date.accessioned2024-04-24T17:08:19Z
dc.date.available2024-04-24T17:08:19Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractChronic venous insufficiency (CVI) is a progressive inflammatory disease. Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in patients with CVI. Eighty patients with CVI were divided into three groups according to clinical class (grade 1, 2 and 3) and score of disease severity (mild, moderate and severe). The basic inflammatory blood markers [ neutrophil, lymphocyte, mean platelet volume (MPV), white blood cell (WBC), platelet, albumin, D-dimer, fibrinogen, fibrinogen to albumin ratio, and neutrophil to lymphocyte ratio] were investigated in each group. Serum neutrophil, lymphocyte, MPV, platelet count, D-dimer and neutrophil to lymphocyte ratio levels were similar among the groups (P>0.05). Although the serum WBC levels were significant in the clinical severity groups (P<0.05), it was useless to separate each severity class. However, albumin, fibrinogen and the fibrinogen to albumin ratio were significant predictors of clinical class and disease severity. Especially, the fibrinogen to albumin ratio was detected as an independent indicator for a clinical class and disease severity with high sensitivity and specificity (75% sensitivity and 87.5% specificity for clinical class and 90% sensitivity and 88.3% specificity for disease severity). Serum fibrinogen and albumin levels can be useful parameters to determine clinical class and disease severity in patients with CVI. Moreover, the fibrinogen to albumin ratio is a more sensitive and specific predictor of the progression of CVI. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.en_US
dc.identifier.doi10.1097/MBC.0000000000000478
dc.identifier.endpage690en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue6en_US
dc.identifier.pmid26650463
dc.identifier.scopus2-s2.0-84949473561
dc.identifier.scopusqualityQ3
dc.identifier.startpage684en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0000000000000478
dc.identifier.urihttps://hdl.handle.net/11468/17297
dc.identifier.volume27en_US
dc.identifier.wosWOS:000380807800012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood Parametersen_US
dc.subjectFibrinogen To Albumin Ratioen_US
dc.subjectSeverityen_US
dc.subjectVenous Insufficiencyen_US
dc.titleSimple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiencyen_US
dc.titleSimple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency
dc.typeArticleen_US

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