The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male rats

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dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorBodakci, Mehmet N.
dc.contributor.authorHatipoglu, Namik K.
dc.contributor.authorSoylemez, Haluk
dc.contributor.authorBasarili, Kemal
dc.contributor.authorTurkcu, Gul
dc.date.accessioned2024-04-24T17:24:13Z
dc.date.available2024-04-24T17:24:13Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To evaluate the possible protective effect of pomegranate extract (PE) on rats following renal ischemia-reperfusion (I/R) injury. Materials and Methods: Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 minutes without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 minutes of reperfusion. I/R PE group were subjected to the same renal I/R as the I/R group were also given 225 mg/kg PE peroral 30 minutes prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. Results: Serum TAC levels were significantly decreased in I/R group when compared with S group (P = 0.001). Serum MDA levels were increased in I/R group; however, it was not statistically significant. In rat kidney tissues, TOS levels and OSI index were significantly increased after I/R injury, while TAC levels were decreased. In I/R PE group, PE reversed the negative effects of I/R injury. PE pretreatment was effective in decreasing tubular necrosis score. Conclusion: PE pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.en_US
dc.identifier.doi10.4103/0974-7796.127029
dc.identifier.endpage50en_US
dc.identifier.issn0974-7796
dc.identifier.issn0974-7834
dc.identifier.issue1en_US
dc.identifier.pmid24669122
dc.identifier.scopus2-s2.0-84896718694
dc.identifier.scopusqualityQ3
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.4103/0974-7796.127029
dc.identifier.urihttps://hdl.handle.net/11468/19532
dc.identifier.volume6en_US
dc.identifier.wosWOS:000218631000009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofUrology Annals
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectKidneyen_US
dc.subjectPomegranate Extracten_US
dc.subjectRaten_US
dc.titleThe protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male ratsen_US
dc.titleThe protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male rats
dc.typeArticleen_US

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