Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study

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dc.authorid0000-0003-4577-4475en_US
dc.authorid0000-0001-8085-7589en_US
dc.authorid0000-0002-3746-1586en_US
dc.contributor.authorElbahr, Umran S.
dc.contributor.authorTekin, Recep
dc.contributor.authorPapic, M.
dc.contributor.authorPandak, Nenad
dc.contributor.authorErdem, Hakan
dc.contributor.authorCan, Fatma Kesmez
dc.contributor.authorAlpat, Saygın Nayman
dc.date.accessioned2024-03-18T08:21:06Z
dc.date.available2024-03-18T08:21:06Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Although anthrax is a rare zoonotic infection, it still causes significant mortality and morbidity. In this multicenter study, which is the largest anthrax case series ever reported, we aimed to describe the factors leading to dissemination of cutaneous anthrax. Methods: Adult patients with cutaneous anthrax from 16 referral centers were pooled. The study had a retrospective design, and included patients treated between January 1, 1990 and December 1, 2019. Probable, and confirmed cases based upon CDC anthrax 2018 case definition were included in the study. A descriptive statistical analysis was performed for all variables. Results: A total of 141 cutaneous anthrax patients were included. Of these, 105 (74%) patients had probable and 36 (26%) had confirmed diagnosis. Anthrax meningitis and bacteremia occurred in three and six patients, respectively. Sequelae were observed in three patients: cicatricial ectropion followed by ocular anthrax (n = 2) and movement restriction on the left hand after surgical intervention (n = 1). One patient had gastrointestinal anthrax. The parameters related to poor outcome (p < 0.05) were fever, anorexia, hypoxia, malaise/fatigue, cellulitis, fasciitis, lymphadenopathy, leukocytosis, high CRP and creatinine levels, longer duration of antimicrobial therapy, and combined therapy. The last two were seemingly the consequences of dissemination rather than being the reasons. The fatality rate was 1.4%. Conclusions: Rapid identification of anthrax is crucial for prompt and effective treatment. Systemic symptoms, disseminated local infection, and high inflammatory markers should alert the treating physicians for the dissemination of the disease.en_US
dc.identifier.citationElbahr U.S., Tekin R., Papic, M., Pandak, N., Erdem, H., Can, F. K. ve diğerleri. (2022). Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study. New Microbes and New Infections, 48, 1-6.en_US
dc.identifier.doi10.1016/j.nmni.2022.101028
dc.identifier.endpage6en_US
dc.identifier.issn2052-2975
dc.identifier.pmid36193102
dc.identifier.scopus2-s2.0-85138759566
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2052297522000804?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13603
dc.identifier.volume48en_US
dc.identifier.wosWOS:000884819700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, Recep
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofNew Microbes and New Infections
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnthraxen_US
dc.subjectBacteremiaen_US
dc.subjectGastrointestinalen_US
dc.subjectMeningitisen_US
dc.subjectMortalityen_US
dc.subjectOutcomeen_US
dc.titleFactors leading to dissemination of cutaneous anthrax: an international ID-IRI studyen_US
dc.titleFactors leading to dissemination of cutaneous anthrax: an international ID-IRI study
dc.typeArticleen_US

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